Skip to main content
SpringerLink
Log in

Tumoren des endokrinen Pankreas

Tumors of the endocrine pancreas

  • Schwerpunkt: Pankreaspathologie
  • Published:
Der Pathologe Aims and scope Submit manuscript

Zusammenfassung

Die neuroendokrinen Tumoren des Pankreas sind insgesamt selten, gehören jedoch zu den häufigsten endokrinen Neoplasien des Abdominalraums. In den meisten Fällen handelt es sich um solitäre Tumoren, aufgebaut aus monomorphen Zellen. Funktionell aktive Tumoren sind mit charakteristischen Syndromen verbunden. Anhand von morphologischen, immunhistochemischen und biologischen Kriterien wird zwischen gut differenzierten Tumoren mit benignem Verhalten oder solchen mit fraglicher Dignität, gut differenzierten (niedrigmalignen) Karzinomen und niedrig differenzierten (hochmalignen) Karzinomen unterschieden. In den letzten Jahren hat der Anteil der nicht-funktionellen Tumoren zugenommen.

Abstract

The neuroendocrine tumors of the pancreas are rare, but belong to the most common endocrine neoplasms of the abdomen. In most cases they present as solitary tumors, composed of monomorphic cells. Functionally active cells are associated with characteristic hormonal syndromes. Using morphological, immunohistochemical and biological criteria, the classification distinguishes between well differentiated tumors with benign or uncertain behavior, well differentiated (low grade malignant) carcinomas and poorly differentiated (high grade malignant) carcinomas. In recent years the percentage of non-functional tumors has increased.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1a–h

Literatur

  1. Bale AE, Norton JA, Wong EL et al. (1991) Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res 51:1154–1157

    CAS  PubMed  Google Scholar 

  2. Beghelli S, Pelosi G, Zamboni G et al. (1998) Pancreatic endocrine tumours: evidence for a tumour suppressor pathogenesis and for a tumour suppressor gene on chromosome 17p. J Pathol 186:41–50

    Article  CAS  PubMed  Google Scholar 

  3. Bloom SR, Polak JM, Pearse AGE (1973) Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet 11:14–16

    Google Scholar 

  4. Capella C, Heitz PU, Höfler H et al. (1995) Revised classification of neuroendocrine tumours of the lung, pancreas and gut. Virchows Arch 425:547–560

    Article  CAS  PubMed  Google Scholar 

  5. Capella C, Polak JM, Buffa R et al. (1983) Morphologic patterns and diagnostic criteria of VIP-producing endocrine tumors. A histologic, histochemical, ultrastructural and biochemical study of 32 cases. Cancer 52:1860–1874

    CAS  PubMed  Google Scholar 

  6. Chung DC, Smith AP, Louis DN et al. (1997) A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications. J Clin Invest 100:404–410

    CAS  PubMed  Google Scholar 

  7. Donow C, Pipeleers-Marichal MA, Schroder S et al. (1991) Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy. Cancer 68:1329–1334

    CAS  PubMed  Google Scholar 

  8. Heitz PU, Klöppel G, Polak JM, Staub JJ (1981) Ectopic hormone production by endocrine tumors: localization of hormones at the cellular level by immunocytochemistry. Cancer 48:2029–2037

    CAS  PubMed  Google Scholar 

  9. Klöppel G, Heitz PU (2000) Tumors of the endocrine pancreas. In: CDM Fletcher (ed) Diagnostic histopathology of tumors, 2nd edn. Churchill Livingstone, London, pp 1083–1098

  10. Klöppel G, Höfler H, Heitz PU (1993) Pancreatic endocrine tumours in man. In: JM Polak (ed) Diagnostic histopathology of neuroendocrine tumours. Churchill Livingstone, Edinburgh, pp 91–121

  11. Klöppel G, Willemer S, Stamm B et al. (1986) Pancreatic lesions and hormonal profile of pancreatic tumors in multiple endocrine neoplasia type I. An immunocytochemical study of nine patients. Cancer 57:1824–1832

    PubMed  Google Scholar 

  12. Komminoth P, Heitz PU, Klöppel G (1998) Pathology of MEN-1: morphology, clinicopathologic correlations and tumour development. J Intern Med 243:455–464

    Article  CAS  PubMed  Google Scholar 

  13. Krejs GJ, Orci L, Conlon JM et al. (1979) Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Engl J Med 301:285–292

    CAS  PubMed  Google Scholar 

  14. La Rosa S, Sessa F, Capella C et al. (1996) Prognostic criteria in nonfunctioning pancreatic endocrine tumours. Virchows Arch 429:323–333

    Article  PubMed  Google Scholar 

  15. Pellegata NS, Sessa F, Renault B et al. (1994) K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res 54:1556–1560

    CAS  PubMed  Google Scholar 

  16. Pipeleers-Marichal MA, Somers G, Willems G et al. (1990) Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. N Engl J Med 322:723–727

    CAS  PubMed  Google Scholar 

  17. Roth J, Klöppel G, Madsen OD et al. (1992) Distribution patterns of proinsulin and insulin in human insulinomas: an immunohistochemical analysis in 76 tumors. Virchows Arch [B] Cell Pathol 63:51–61

    Google Scholar 

  18. Shan L, Nakamura Y, Nakamura M et al. (1998) Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors. Lab Invest 78:471–475

    CAS  PubMed  Google Scholar 

  19. Solcia E, Capella C, Klöppel G (1997) Tumors of the pancreas. AFIP Atlas of Tumor Pathology, 3rd series, fascicle 20. Armed Forces Institute of Pathology, Washington/DC

  20. Solcia E, Klöppel G, Sobin LH (In collaboration with 9 pathologists from 4 countries) (2000) Histological typing of endocrine tumours, 2nd edn. WHO international histological classification of tumours. Springer, Berlin Heidelberg New York Tokyo

Download references

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Author information

Authors and Affiliations

  1. Institut für Allgemeine Pathologie, Universität Kiel

    M. Anlauf, B. Sipos & G. Klöppel

  2. Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Michaelisstr. 11, 24105l, Kiel

    M. Anlauf

Authors
  1. M. Anlauf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Sipos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Klöppel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Anlauf.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anlauf, M., Sipos, B. & Klöppel, G. Tumoren des endokrinen Pankreas. Pathologe 26, 46–51 (2005). https://doi.org/10.1007/s00292-004-0727-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00292-004-0727-0

Schlüsselwörter

Keywords

Search

Navigation