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Neuroendokrine Tumoren der Lunge

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Zusammenfassung

Neuroendokrine Tumoren der Lunge können heute unter Berücksichtigung immunhistochemischer Zusatzbefunde in Biopsie- und Operationspräparaten zuverlässig als eigene Entität der Lungentumoren entsprechend den Empfehlungen der WHO-Klassifikation 1999 zusammengefasst werden.

Die für klinische Fragestellungen und therapeutische Maßnahmen differenzierte Charakterisierung von Karzinoidtumoren und kleinzelligen Karzinomen nach histomorphologischen und zytologischen Kriterien durch den Pathologen ist allgemein akzeptiert und von entscheidender Bedeutung.

Unklar bleibt bisher, ob die "neue" Gruppe der großzelligen neuroendokrinen Karzinome der Lunge eine eigene Tumorentität mit klinischer und therapeutischer Relevanz bildet oder weiterhin nur als besondere Differenzierungsvariante in der Gruppe der "nichtkleinzelligen Karzinome" zu führen ist. Dieser Fragenkomplex kann künftig nur durch gezielte Studien zu Krankheitsverläufen und Therapieergebnissen geklärt werden.

Abstract

Neuroendocrine tumors of the lung can be seen as a separate entity, in accordance with the recommendations of the WHO classification of 1999, in terms of immunohistochemical findings in biopsy material as well as in more extensive resections.

The characterization of carcinoid tumors and small cell lung cancer by the pathologist according to histomorphological and cytological criteria is commonly accepted, and is of decided importance with regard to clinical questions and therapeutic measures.

However, it is still unclear whether the "new" group of large cell neuroendocrine carcinomata of the lung has to be regarded as a separate entity with clinical and therapeutic relevance, or whether this group remains within the non-small cell lung cancers as a special form of differentiation.

These complex questions can only be answered by studies targeting the course of the disease and the results of therapy.

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Authors and Affiliations

  1. Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Klinikum der Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum

    K.-M. Müller

  2. Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Klinikum der Ruhr-Universität Bochum

    K.-M. Müller

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Müller, KM. Neuroendokrine Tumoren der Lunge. Pathologe 24, 297–302 (2003). https://doi.org/10.1007/s00292-003-0624-y

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  • DOI: https://doi.org/10.1007/s00292-003-0624-y

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