An alternative approach for deprotection of triphenylmethyl cellulose

Summary

The triphenylmethyl (trityl) moiety is often used to protect primary hydroxy groups of polysaccharides. In this work a new procedure of the deprotection of trityl cellulose is described. Molten salt hydrates like LiClO₄ ^*3H₂O and ZnCl₂ ^*4H₂O were firstly used as media for this reaction. The complete deprotection of trityl cellulose occurs in comparatively short reaction time (3–5 hours). The completeness of the detritylation reaction was demonstrated by means of FT-IR and ¹³C CP/MAS NMR spectroscopy.