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Chitosan gel beads as drug carriers 2. Release of 8-hydroxy-7-iodoquinoline-5-sulfonic acid and 2,5-dihydroxybenzenesulfonic acid

2. Release of 8-hydroxy-7-iodoquinoline-5-sulfonic acid and 2,5-dihydroxybenzenesulfonic acid

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Summary

It is shown that chitosan gel beads are suitable carriers of 8-hydroxy-7-iodoquinoline-5-sulfonic acid (SQ) and 2,5-dihydroxybenzenesulfonic acid (DHBSA) - substances applied in medicine. Drug release has been investigated with respect to the nature of the crosslinking agent (epichlorohydrin or glutaraldehyde) and pH of the medium. Considerable differences in the release rate of DHBSA and SQ have been found. The total amount of the desorbed SQ, as well as the release rate of the drug depends on pH of the medium - they decrease from alkaline to acidic medium. The antimicrobial and antimycotic activity of the loaded with SQ beads is demonstrated.

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Authors and Affiliations

  1. Institute of Polymers,, , , , , , BG

    N. Koseva, N. Manolova & I. Rashkov

  2. Institute of Microbiology, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria, , , , , , BG

    N. Markova & T. Radoucheva

Authors
  1. N. Koseva
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  2. N. Manolova
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  3. N. Markova
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  4. T. Radoucheva
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  5. I. Rashkov
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Received: 20 November 1998/Revised version: 5 April 1999/Accepted: 24 June 1999

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Koseva, N., Manolova, N., Markova, N. et al. Chitosan gel beads as drug carriers 2. Release of 8-hydroxy-7-iodoquinoline-5-sulfonic acid and 2,5-dihydroxybenzenesulfonic acid. Polymer Bulletin 43, 101–107 (1999). https://doi.org/10.1007/s002890050539

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  • DOI: https://doi.org/10.1007/s002890050539

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