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Syntheses and biological activities of 5′-O-methacryloyl-3′-azido-3′-deoxythymidine and its polymers

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Summary

The new monomer, 5′-O-methacryloyl-3′-azido-3′-deoxythymidine (MAZT), was synthesized from methacryloyl chloride(MAC) and 3′-azido-3′-deoxythymidine(AZT). The homopolymer of MAZT and copolymers of MAZT with acrylic acid (AA) or exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic glycinylimide (ETGI) were synthesized by radical polymerizations. The structures of MAZT and polymers were confirmed identified by FT-IR and 1H-NMR spectroscopies. The number average molecular weights (Mn) and polydispersity indices of the synthesized polymers were in the range of 4,400 ∼ 20,400 and 1.2 ∼ 2.0. The in vitro cytotoxicities of polymers against K562 human leukemia and normal cell lines were greater than that of control.

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, Pusan National University, Pusan, 609-735, Korea

    Won-Moon Choi, Chang-Sik Ha & Won-Jei Cho

  2. Department of Premedical Sciences, Kosin University, Pusan, 602-702, Korea

    Neung-Ju Lee

  3. Department of Neurosurgery, School of Medicine, Pusan National University, Pusan, 602-739, Korea

    Young-Woo Lee

Authors
  1. Won-Moon Choi
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  2. Neung-Ju Lee
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  3. Young-Woo Lee
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  4. Chang-Sik Ha
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  5. Won-Jei Cho
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Choi, WM., Lee, NJ., Lee, YW. et al. Syntheses and biological activities of 5′-O-methacryloyl-3′-azido-3′-deoxythymidine and its polymers. Polymer Bulletin 39, 535–542 (1997). https://doi.org/10.1007/s002890050183

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  • DOI: https://doi.org/10.1007/s002890050183

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