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Determination of gentamicin by using square wave anodic stripping voltammetry with poly (β-cyclodextrin-p-toluene sulfonic acid) modified glassy carbon electrode

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Abstract

In this study, an effective electrochemical method based on modified glassy carbon electrode was developed for the determination of gentamicin. Firstly, the poly β-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode as gentamicin selective electrode was prepared by electropolymerization technique. In situ electropolymerization of β-cyclodextrin and p-toluene sulfonic acid was conducted on bare glassy carbon electrode by controlled potential cycling. Characterization of the prepared poly β-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode was performed using cyclic voltammetry and electrochemical impedance spectroscopy. Then, the effects of various parameters were investigated using square wave anodic stripping voltammetry in citrate buffer containing 4.0 mmol L−1 gentamicin. The calibration graph plotted over the range of 0.06–4.0 mmol L−1 gentamicin concentration showed high linearity. Correlation coefficient, detection limit and quantitation limit were obtained from the calibration graph as 0.9999, 3.7 µmol L−1 and 12.4 µmol L−1, respectively. According to these results, it is seen that the prepared poly β-cyclodextrin-p-toluene sulfonic acid/glassy carbon electrode can be successfully used for the determination of gentamicin in many pharmacological, medical and biochemical applications.

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Acknowledgements

The financing of this study is İnönü University Scientific Research Projects Coordination and it was supported by the project numbered FYL-2018-1504. GNS electrochemical reaction mechanism was suggested by Prof. Dr. Ülkü Yılmaz.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, İnönü University, 44280, Malatya, Türkiye

    Muammer Burç, Serap Titretir Duran & Öznur Güngör

  2. Department of Chemistry, Faculty of Arts and Sciences, Adnan Menderes University, 09010, Aydın, Türkiye

    Ali Ersin Karagözler

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This article is dedicated to memory of Prof. Dr. O. Yavuz Ataman, a brilliant Turkish scientist working in Analytical Chemistry, who passed away on August 15, 2020.

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Burç, M., Titretir Duran, S., Güngör, Ö. et al. Determination of gentamicin by using square wave anodic stripping voltammetry with poly (β-cyclodextrin-p-toluene sulfonic acid) modified glassy carbon electrode. Polym. Bull. 81, 6381–6403 (2024). https://doi.org/10.1007/s00289-023-05011-0

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