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High-sensitivity electrochemical sensor using no nanomaterials for the detection of ciprofloxacin with poly 2-(hydroxymethyl)thiophene-modified glassy carbon electrode

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Abstract

In this study, a new sensor was developed for the detection of ciprofloxacin that is easy to prepare, selective and has excellent sensitivity through electrochemical polymerization of 2-(hydroxymethyl)thiophene on glassy carbon (GC) electrode. Electrode modifications were performed by using cyclic voltammetry. The morphology and surface properties of the modified electrode were characterized by using scanning electron microscopy. Determination of ciprofloxacin with poly 2-(hydroxymethyl)thiophene-modified GC electrode was performed by square wave voltammetry in 0.1 M citrate buffer (pH 5.00) at 1.1 V. The prepared sensor showed a wide linear range from 0.1 to 200 µM, detection limit of 7 nM, a limit of quantitation of 22 nM, a correlation coefficient of 0.9993, excellent sensitivity of 99.6% and a relative standard deviation of 0.40%. The sensor was used to determine ciprofloxacin in human urine samples, and a recovery efficiency of 99.24–100.36% was obtained. According to the results in this study, we believe that the sensor developed can be used for the detection of ciprofloxacin in clinical laboratories.

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Acknowledgment

This study was supported financially by İnönü University Scientific Research Projects Coordination Unit with the project numbered FYL-2018-1504. We thank Andrea Holck Karagözler for her help in editing the grammar and spelling errors of the manuscript.

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  1. Department of Chemistry, Faculty of Arts and Sciences, İnönü University, 44280, Malatya, Türkiye

    Muammer Burç, Öznur Güngör & Serap Titretir Duran

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Burç, M., Güngör, Ö. & Titretir Duran, S. High-sensitivity electrochemical sensor using no nanomaterials for the detection of ciprofloxacin with poly 2-(hydroxymethyl)thiophene-modified glassy carbon electrode. Polym. Bull. 81, 6283–6310 (2024). https://doi.org/10.1007/s00289-023-04995-z

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