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Preparation of new eco-friendly covalent dynamic network based on polylysine, cellulose nanowhisker dialdehyde, and chitosan for curcumin delivery

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Abstract

Dynamic covalent hydrogels are considered smart materials with a stimuli-sensitive nature and possessing great importance in biomedical applications. In the current work, a new hydrogel based on polylysine (PLL), cellulose nanowhisker dialdehyde (DACNW), and chitosan (Cs) containing pH-sensitive dynamic covalent imine bonds was synthesized and along with its synthesis its potential application in curcumin (CUR) delivery was studied. Also, the antibacterial activities of hydrogel and drug-loaded hydrogels were evaluated. The prepared hydrogel also was characterized using techniques such as XRD, UV–VIS, FE-SEM, TGA, FT-IR and 1H-NMR spectroscopy. The resulting hydrogel showed excellent pH dependent curcumin delivery. Moreover, curcumin-loaded hydrogel showed good antibacterial activity against both Gram-negative and Gram-positive bacteria. The resulting hydrogel due to its pH-sensitive imine bonds could be considered as smart anticancer drug carrier system with high antibacterial properties.

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Acknowledgements

We gratefully acknowledge the financial support of the Lorestan University.

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  1. Chemistry Department, Faculty of Science, Lorestan University, Khorramabad, Lorestan, Iran

    Samira Razani & Abbas Dadkhah Tehrani

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  1. Samira Razani
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Razani, S., Dadkhah Tehrani, A. Preparation of new eco-friendly covalent dynamic network based on polylysine, cellulose nanowhisker dialdehyde, and chitosan for curcumin delivery. Polym. Bull. 81, 4893–4909 (2024). https://doi.org/10.1007/s00289-023-04938-8

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