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Study of anti-inflammatory and anti-arthritic potential of curcumin-loaded Eudragit L100 and hydroxy propyl methyl cellulose (HPMC) microparticles

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Abstract

Curcumin is derived from Curcuma longa's dried root rhizomes possessing extensive variety of therapeutic actions such as antifungal, anti-inflammatory, antibacterial, antispasmodic, antioxidant and anti-arthritic. The current study was conducted to fabricate, characterize and optimize curcumin-loaded Eudragit L100 and hydroxy propyl methyl cellulose (HPMC) sustained release and improved bioavailable microparticles for anti-arthritis and anti-inflammatory activities. Curcumin-loaded microparticles made with Eudragit L100 and HPMC via ESE having different polymer and emulsifier concentrations. Optical microscope showed spherical microparticles, and FTIR spectroscopic analysis displayed characteristic peaks at 3519 cm−1, 1366 cm−1, 950 cm−1 and 728 cm−1 due to O–H group, C–OH bending and bending vibration of –CH groups, respectively. SEM analysis showed that mean microparticles diameter was 30.2–76.7 μm having encapsulation efficiency 78.8–96.2%. Curcumin (600 µg/ml) showed 52%HRBC membrane stabilization and 71% protein denaturation inhibition. Curcumin (600 µg/ml) produced microparticles with 30.2 μm-diameter showed highest encapsulation, sustained drug release, significant anti-arthritic potential with good anti-inflammatory activity make it suitable as new therapeutic anti-arthritic agent. From results, it was suggested that this is a promising strategy for the development and treatment of chronic ailments like arthritis and inflammation.

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Acknowledgements

Authors are thankful to department of University College of Conventional Medicine for their financial as well as moral support to accomplish this study successfully.

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Authors and Affiliations

  1. College of Conventional Medicine, Islamia University of Bahawalpur, Bahawalpur, Pakistan

    Sehrish Rana Rajpoot, Hafiz Muhammad Asif, Farah Zafar, Hafiz Abdul Sattar Hashmi, Muhammad Rahil Aslam & Abdul Hayee

  2. Department of Chemistry, University of Management and Technology (UMT), Sialkot Campus, Punjab, Pakistan

    Khalil Ahmad & Hammad Majeed

  3. Department of Pharmaceutics, Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Pakistan

    Muhammad Asadullah Madni

  4. Department of Zoology, Islamia University, Bahawalpur, Pakistan

    Muhammad Wasim Tasleem

  5. Department of Biochemistry, Lahore Garrison University (LGU), Lahore, Pakistan

    Aisha Khalid

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  1. Sehrish Rana Rajpoot
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Correspondence to Khalil Ahmad.

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Rajpoot, S.R., Ahmad, K., Asif, H.M. et al. Study of anti-inflammatory and anti-arthritic potential of curcumin-loaded Eudragit L100 and hydroxy propyl methyl cellulose (HPMC) microparticles. Polym. Bull. 81, 4335–4350 (2024). https://doi.org/10.1007/s00289-023-04899-y

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