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A comparative study of the interactions of 5-fluorouracil and Amlodipine Besylate in aqueous β-cyclodextrin solution and drug release studies

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Abstract

5-Fluorouracil is a chemotherapeutic agent used for the treatment of different kinds of cancers and Amlodipine Besylate is a vasodilator used to cure hypertension and angina. In order to improve different properties of drugs like drug solubility, mask bitter taste, prevent photodegradation, and for controlled drug delivery, the host–guest, solid inclusion complexes of 5-flurouracil (5-FU) and Amlodipine Besylate (ABS) with beta-cyclodextrin (β-CD) were utilized for different studies in this manuscript which were prepared through traditional methods and microwave-prompted technique. Different parameters such as apparent molar volume (Vϕ), partial molar volume at infinite dilution (Vϕ0), apparent molar isentropic compression (Kϕ,s), partial molar isentropic compression at infinite dilution (K0ϕ,s) were obtained from experimental density and speed of sound data. The partial molar volume at infinite dilution (Vϕ0 × 106/m3 mol−1) values of β-CD in aqueous solution of drug ABS was found 79.83, 80.32 and 80.64 at 305.15, 310.15 and 315.15 K, respectively. The partial molar volume at infinite dilution (Vϕ0 × 106/m3 mol−1) values of β-CD in aqueous solution of drug 5-FU was found − 252.61, − 246.42 and − 255.74 at 305.15, 310.15 and 315.15 K, respectively. The value of solubility constant (Ks) was found to be 74.3822 ± 4 M−1 for 5-FU and 204.0811 ± 4.75 M−1 for ABS in phase solubility studies. The inclusion complexes (ICs) were incorporated into the hybrid polymer networks (HPNs) of chitosan and gelatin to explore drug release studies. A comparison of directly loaded drug into the HPNs was made with the cyclodextrin-mediated release. The ICs prepared by different methods were also compared for the drug release.

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Abbreviations

IC:

Inclusion complex

HPN:

Hybrid polymer network

ABS:

Amlodipine Besylate

β-CD:

Beta cyclodextrin

MW:

Microwave

5-FU:

5-Flurouracil

CH:

Chitosan

GEL:

Gelatin

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Acknowledgements

The author is also grateful to the Materials research centre, MNIT Jaipur, for testing samples and DST-FIST for providing economic assistance for purchase of equipments like FTIR and UV-Visible spectrophotometer used in the characterization of the synthesized materials.

Funding

Financial assistance for a part of this research work was provided by Ministry of Education (Reg No. 15520006). Therefore, the author pays her gratitude to the organization.

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Authors and Affiliations

  1. Faculty of Natural Sciences, GNA University, Phagwara, Punjab, 144401, India

    Kuljit Kaur

  2. Polymer and Nanomaterials Lab, Department of Chemistry, Dr B R Ambedkar National Institute of Technology, Jalandhar, Punjab, 144011, India

    Rajeev Jindal

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Correspondence to Kuljit Kaur.

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Kaur, K., Jindal, R. A comparative study of the interactions of 5-fluorouracil and Amlodipine Besylate in aqueous β-cyclodextrin solution and drug release studies. Polym. Bull. 81, 2719–2740 (2024). https://doi.org/10.1007/s00289-023-04859-6

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