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Microwave-assisted grafting of acrylamide on a natural xylan gum for controlled drug delivery

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Abstract

Natural polymers offer significant advantages (biocompatibility, biodegradability, and non-toxicity) over synthetic polymers besides some reported disadvantages. However, natural polymeric structures can be modified by the grafting process for desired physicochemical properties. The purpose of the present research was to develop polyacrylamide-grafted xylan gum (XG) via green synthesis using microwave-assisted free radical polymerization with the use of ceric ammonium nitrate (initiator). Several batches of the grafted XG were prepared by varying three independent process variables (amount of acrylamide, ceric ammonium nitrate, and microwave irradiation time) and subsequently characterized for surface, physicochemical, and biodegradation properties. The grafted XG from the optimized batch was further used in the preparation of metoprolol succinate tablets, which showed desired properties including in vitro controlled release of highly water-soluble drug for more than 8 h following zero-order kinetics as the best-fit model. Therefore, the grafted XG, prepared using the microwave-assisted graft copolymerization method, proved its efficiency as an excellent pharmaceutical excipient for its use in controlled release systems for drugs with high aqueous solubility.

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Data availability statement

The raw/processed data required to reproduce these findings cannot be shared at this time as the data also form part of an ongoing study.

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Acknowledgements

There was no funding received from any agency to carry out the research work or for the preparation of this article.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013, India

    Siddharth P. Phalle & Praffula B. Choudhari

  2. Department of Pharmaceutical Analysis, Sarojini College of Pharmacy, Kolhapur, Maharashtra, 416013, India

    Sujata P. Choudhari

  3. Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416013, India

    Durgacharan A. Bhagwat

  4. Department of Pharmaceutics, Ashokrao Mane Institute of Pharmacy, Ambap, Kolhapur, Maharashtra, 416112, India

    Atul M. Kadam

  5. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, 844 102, India

    Vinod L. Gaikwad

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  1. Siddharth P. Phalle
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Correspondence to Vinod L. Gaikwad.

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Phalle, S.P., Choudhari, P.B., Choudhari, S.P. et al. Microwave-assisted grafting of acrylamide on a natural xylan gum for controlled drug delivery. Polym. Bull. 81, 2583–2600 (2024). https://doi.org/10.1007/s00289-023-04853-y

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