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Propyl modification of Moringa gum for drug delivery applications

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Abstract

The present work represents the propyl modification and characterization of Moringa gum for sustained drug delivery applications. The propylation of Moringa gum was performed using n-propyl bromide by alkyl etherification process. The propylated Moringa gum was further evaluated as a diclofenac sodium-loaded matrix tablet and composite beads for sustained drug delivery. The modification of Moringa gum was confirmed by infrared spectroscopy. The degree of propyl substitution was determined to be 0.407. The characterization studies revealed the increase in the degree of crystallinity, thermal stability, surface roughness, and the decrease in viscosity on propyl modification. The native and modified gum had a molecular weight of 1.02 × 104 and 4.84 × 104 KDa, respectively. The diclofenac-loaded matrix tablets of Moringa gum disintegrated in simulated gastric fluid, while tablets of propyl Moringa gum provided sustained release of diclofenac by super case 2 transport following Higuchi release kinetics. The ionically gelled beads of propyl Moringa gum were able to control the burst release of diclofenac in simulated gastric fluid releasing 84% of the drug in 24 h following Higuchi kinetics. It can be concluded that the propyl-modified Moringa gum can be used as a pharmaceutical excipient for sustained drug delivery applications.

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Acknowledgements

The authors express gratitude to the Coordinator, DST-FIST, Department of Physics, GJUST, Hisar (SR/FST/PSI-089-2005), for providing us with the facilities for X-ray diffraction studies, and the Director, Dr APJ Abdul Kalam Central Instrumentation Laboratory, GJUST, Hisar, for FT-IR, SEM, and rheology analysis.

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India

    Atul Kaushik, Shashi Yadav, Priya Mudgal, Rimpy Pahwa & Munish Ahuja

  2. Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh, 123031, Haryana, India

    Tarun Kumar

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  1. Atul Kaushik
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Correspondence to Munish Ahuja.

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Kaushik, A., Yadav, S., Mudgal, P. et al. Propyl modification of Moringa gum for drug delivery applications. Polym. Bull. 81, 2643–2670 (2024). https://doi.org/10.1007/s00289-023-04840-3

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  • DOI: https://doi.org/10.1007/s00289-023-04840-3

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