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Nano TiO2-doped sodium alginate/hydroxypropyl methylcellulose synthesis of bionanocomposite membrane and its use in controlled release of anti-cancer drug 5-fluorouracil

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Abstract

Today, the disease treatment aims to increase the patient's quality of life, reduce the dose of drugs used, extend the dosing interval, and purify the patient from the side and harmful effects. Controlled drug release systems are the systems that respond best in this respect. In this study, the evaluation of the in vitro release of 5-fluorouracil for the transdermal delivery system of NaAlg/HPMC/TiO2 biocompatible membranes was investigated. The nanocomposite membrane was prepared by adding TiO2 nanoparticles to a mixture of sodium alginate and hydroxypropyl methylcellulose polymers. Membranes were analyzed by Fourier Transform Infrared, Scanning Electron Microscopy, Differential Scanning Calorimetry, X-Ray Diffraction, and Thermogravimetric analyses. In addition, water contact angles and mechanical tests of the membranes were carried out. The degree of swelling of the prepared membranes was examined; the highest swelling degree was obtained as 304.9% in pH 5.0 buffer. The effects of crosslinking time, nanoparticle amount, and temperature were investigated in the release studies of 5-FU. The highest drug release was found to be 65.3% at the end of 24 h in membranes containing 5% TiO2 and crosslinked for 1 h. The release kinetics of 5-FU were evaluated according to four kinetic models, and the release from NaAlg/HPMC/TiO2 membranes showed conformity with the Korsmeyer–Pappes model.

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  1. Yıldızeli Vocational High School, Sivas Cumhuriyet University, Sivas, Turkey

    Gülşen Taşkın Çakıcı

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Taşkın Çakıcı, G. Nano TiO2-doped sodium alginate/hydroxypropyl methylcellulose synthesis of bionanocomposite membrane and its use in controlled release of anti-cancer drug 5-fluorouracil. Polym. Bull. 80, 12719–12740 (2023). https://doi.org/10.1007/s00289-023-04674-z

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