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Effect of additives on fabrication and properties of hydroxypropyl methylcellulose-based hydrogels

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Abstract

Hydrogel materials based on bio-degradable polymers have received a lot of interest owing to many potential applications. In this study, hydroxypropyl methylcellulose (HPMC) as a based polymer was cross-linked using 5 wt% of non-toxic citric acid. Polyethylene glycol (PEG) and glycerol were used as gelation accelerants. The effect of reaction temperature on the ability to cross-link the matrix was investigated using differential scanning calorimetry (DSC), thermogravimetric (TGA), and dynamic mechanical analysis (DMA). The cross-linking process could not be observed using DSC or TGA. However, the sample with PEG and glycerol exhibited the highest increase of storage modulus in DMA measurement. A completely gelled state (100% gel fraction) could be obtained in all sample types at the temperature of 140 °C for 10 h. The addition of PEG significantly improved the gel fraction of HPMC-based hydrogel. With a higher concentration of PEG, the increase of C = O groups which were a result of the esterification of citric acid and HPMC molecule was confirmed by Fourier transform infrared spectroscopy (FTIR). The sample with 1 wt% of PEG showed the highest methylene blue adsorption.

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Authors and Affiliations

  1. Faculty of Chemical Engineering, Ho Chi Minh City University of Food Industry, 140 Le Trong Tan Street, Tay Thanh Ward, Tan Phu District, Ho Chi Minh City, Vietnam

    Ha N. Giang & Anh T. K. Le

  2. Faculty of Chemical and Food Technology, Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, Vietnam

    Tuan N. A. Huynh

  3. Department of Chemical Engineering, School of Chemical and Environmental Engineering, International University, Ho Chi Minh City, Vietnam

    Thanh Khoa Phung

  4. Vietnam National University, Ho Chi Minh City, Vietnam

    Thanh Khoa Phung

  5. Faculty of Materials Science and Engineering, Kyoto Institute of Technology, Kyoto, Japan

    Wataru Sakai

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  1. Ha N. Giang
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Giang, H.N., Le, A.T.K., Huynh, T.N.A. et al. Effect of additives on fabrication and properties of hydroxypropyl methylcellulose-based hydrogels. Polym. Bull. 80, 11121–11137 (2023). https://doi.org/10.1007/s00289-022-04610-7

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