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Ibuprofen-loaded UHMWPE for orthopedics applications: preliminary evaluation of mechanical and biological properties

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Abstract

Although ibuprofen has been employed as a postoperative treatment in TJR to reduce inflammation, the incorporation of this drug on UHMWPE bearing components prior to implantation is incipient. The present study investigated the effect of the incorporation ibuprofen into the polymeric matrix of UHMWPE. Particularly, the mechanical, tribological, and biological properties of ibuprofen-loaded UHMWPE were evaluated. Dynamic-mechanical, wear, and tensile strength tests were performed to evaluate the influence of drug on polymer mechanical properties. No difference between formulations was verified in dynamic-mechanical properties and wear resistance. The effect of drug release on tensile strength was also investigated before and after 30 days of in vitro immersion. Although presenting a difference in modulus prior and after release tests, modulus and tensile yield stress remained inside the range indicated to UHMWPE used in orthopedic implants. Furthermore, after drug elution UHMWPE 3% IBU and UHMWPE 5% IBU recovered original UHMWPE properties. Cytotoxicity assessment was performed and both ibuprofen-based formulations were considered nontoxic according to ISO 10993–5.

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Acknowledgments

The authors would like to thank CAPES (I.M.G and L.S.S), and CNPQ (G.V.S and C.R.M.R) for financial support.

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Authors and Affiliations

  1. Laboratório de Engenharia Biomecânica, Hospital Universitário, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brasil

    Izabelle de Mello Gindri, Loise Silveira da Silva, Gean Vitor Salmoria & Carlos Rodrigo de Mello Roesler

  2. Núcleo de Inovação em Moldagem e Manufatura Aditiva, Departamento de Engenharia Mecânica, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brasil

    Gean Vitor Salmoria

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  1. Izabelle de Mello Gindri
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  2. Loise Silveira da Silva
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Correspondence to Loise Silveira da Silva.

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de Mello Gindri, I., Silveira da Silva, L., Vitor Salmoria, G. et al. Ibuprofen-loaded UHMWPE for orthopedics applications: preliminary evaluation of mechanical and biological properties. Polym. Bull. 80, 10907–10919 (2023). https://doi.org/10.1007/s00289-022-04598-0

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