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Antimicrobial incorporation on 3D-printed polymers used as potential dental materials and biomaterials: a systematic review of the state of the art

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Abstract

The association of 3D-printed polymers and incorporation with antimicrobial agents is reported to be effective against different microorganisms. Due to a large number of articles, different polymers, antimicrobial agents, and the heterogeneity of methods, understanding the results becomes difficult, so a systematic review is necessary. The objective of this systematic review is to demonstrate the current state of the art of incorporating antimicrobial agents into printed polymers as potential dental materials and biomaterials. The review was structured in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines and was registered with the Open Science Framework (OSF) (osf.io/sym4c). Searches were performed in Embase, Pubmed, Science Direct, and Scopus databases. The articles were selected in 2 steps by 2 independent reviewers to the eligibility criteria. The Joanna Briggs Institute-adapted quasi-experimental study evaluation tool was used to assess the risk of bias. The incorporation demonstrated a high capacity of antimicrobial effect against several microorganisms, including Streptococcus mutans, Staphylococcus aureus, Candida scotti, Escherichia coli, Staphylococcus epidermidis, and Candida albicans. The studies identified in this systematic review showed a good interaction between the technologies, which allowed the combination of polymers and antimicrobials, demonstrating efficacy against several species, in addition to the chemical, mechanical, and biological properties presenting good results.

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  1. Department of Dental Materials and Prosthodontics, Ribeirão Preto Dental School-FORP-USP, University of São Paulo (USP), Av. Do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil

    Murilo Rodrigues de Campos, André Luis Botelho & Andréa Cândido dos Reis

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  1. Murilo Rodrigues de Campos
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de Campos, M.R., Botelho, A.L. & dos Reis, A.C. Antimicrobial incorporation on 3D-printed polymers used as potential dental materials and biomaterials: a systematic review of the state of the art. Polym. Bull. 80, 7313–7340 (2023). https://doi.org/10.1007/s00289-022-04427-4

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