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Nanoencapsulated α-terpineol attenuates neuropathic pain induced by chemotherapy through calcium channel modulation

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Abstract

Although chemotherapy-induced peripheral neuropathy is one of the main medical complaints of cancer patients, there are currently no specific drugs for the effective treatment. In this respect, α-terpineol (TP) seems to be a potential candidate for this purpose, since it has several pharmacological properties that can be improved by nanosytems. Therefore, the objective of this study was to develop and investigate an antinociceptive action of TP in nanocapsules (TP-LNC) on a peripheral neuropathy induced by paclitaxel (PTX) in mice. Nanocapsules were obtained through the interfacial deposition of preformed polymer method and physicochemically characterized. The effect of TP and TP-LNC was assessed using the hyperalgesia test in mice with neuropathy induced by PTX (32 mg/kg, i.p.). Its effect on calcium channels was evaluated by patch-clamp and molecular docking. TP-LNC presented satisfactory stability and encapsulation efficiency of 64.5%; it also prolonged the antihyperalgesic effect when cooperated with free TP. Moreover, it was found that TP presented molecular interactions with different channels for calcium, being able to reduce calcium currents. These findings bring new evidence about the analgesic action of TP and its modulating action of calcium channels and reiterate the benefits of the encapsulation of monoterpenes in nanosystems.

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Acknowledgements

This research was funded by grants from the Brazilian agencies, National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq), Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—CAPES), Foundation to Support Research and Technological Innovation of the State of Sergipe (Fundação de Apoio à Pesquisa e a Inovação Tecnológica do Estado de Sergipe—FAPITEC/SE) and Funder of Studies and Projects (Financiadora de Estudos e Projetos—FINEP). We thank Prof. Dr. Jader Cruz for his collaboration in conducting electrophysiological experiments carried out at the Federal University of Minas Gerais. We also thank teacher Abilio Borghi for the assistance with the English language review.

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Author notes

  1. Daniele N. Gouveia and Adriana G. Guimarães have contributed equally to this work.

Authors and Affiliations

  1. Department of Physiology, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil

    Daniele N. Gouveia, Marlange A. Oliveira, Thallita K. Rabelo, Iggo K. S. Almeida, Jullyana S. S. Quintans & Lucindo J. Quintans-Júnior

  2. Department of Pharmacy, Federal University of Sergipe, São Cristóvão, SE, 49100-000, Brazil

    Adriana G. Guimarães, Lícia T. S. Pina, Wagner B. R. Santos, Tatianny A. Andrade, Mairim Russo Serafini, Bruno S. Lima & Adriano A. S. Araújo

  3. Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, 30161970, Brazil

    José Evaldo R. Menezes-Filho & Artur Santos-Miranda

  4. Federal University of Paraíba, João Pessoa, PB, Brazil

    Luciana Scotti & Marcus Tullius Scotti

  5. Regional University of Cariri, URCA, Crato, Brazil

    Henrique Douglas Melo Coutinho

  6. Department of Agricultural Sciences, University of Naples Federico II, Portici, Naples, Italy

    Raffaele Capasso

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  1. Daniele N. Gouveia
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Correspondence to Henrique Douglas Melo Coutinho or Lucindo J. Quintans-Júnior.

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Gouveia, D.N., Guimarães, A.G., Oliveira, M.A. et al. Nanoencapsulated α-terpineol attenuates neuropathic pain induced by chemotherapy through calcium channel modulation. Polym. Bull. 80, 2515–2532 (2023). https://doi.org/10.1007/s00289-022-04161-x

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