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Recent advancements of electrospun nanofibers for cancer therapy

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Abstract

Nanotechnology is a rapidly increasing scientific field due to its immense potential for developing new materials with exceptional structure-dependant characteristics through electrospinning as a feasible technique for producing nanofibers having a wide range of potential applications in cancer detection and diagnostics. Cancer is one of the most deadly diseases that has been afflicting humans for many decades. When dealing with cancer, a regulated and continuous drug release is much desired and effective, because such drugs can cause damage to normal cells. Owing to the high-dose requirements for general anticancer drugs utilized during chemotherapy, they have serious side effects. Anticancer drug-laden nanofibers have been accomplished using nanotechnology for treating cancer, requiring less drug because the drug is stored in these nanofibers for an extended period of time with a tunable drug release profile. Due to the fact that electrospun nanofibers are one of the most advantageous and rapidly evolving products of modern technology, they are promising candidates for cancer therapy. Although numerous research reports have been published on the application of nanofibers, few have focused exclusively on the use of nanofibers in cancer care. Thus, this analysis not only provides a fundamental understanding of the mechanism of electrospinning process and the properties of nanostructured fibrous materials, but also highlights the electrospinning technique's potential as a promising tool for fabricating polymeric nanofibers used for cancer therapy.

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Abbreviations

NFs:

Nanofibers

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  1. Department of Polymer and Surface Engineering, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400019, India

    Ekta Jagtiani & Anagha S. Sabnis

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Jagtiani, E., Sabnis, A.S. Recent advancements of electrospun nanofibers for cancer therapy. Polym. Bull. 80, 1215–1242 (2023). https://doi.org/10.1007/s00289-022-04153-x

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