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Synthesis and characterization of nanoparticles based on chitosan-biopolymers systems as nanocarrier agents for curcumin: study on pharmaceutical and environmental applications

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In the present study, a combination of nanosized chitosan with different biodegradable and natural polymers, including Pectin (PEC), β-cyclodextrin (β-CD), sodium alginate (ALG), and polyvinyl alcohol (PVA) by using ionic gelation technique in the presence of Sodium tripolyphosphate (TPP) as a crosslinker, was synthesized and considered a nanocarrier agent for curcumin. Analytical techniques such as UV–Vis Spectrophotometry, Fourier transform infrared spectroscopy (FT-IR), Field emission Scanning Electron Microscopy (FE-SEM), Polydispersity indexes (PDI), and zeta potential have been employed to characterize the nanocarriers. In addition to the morphological and physicochemical properties of the drug delivery systems obtained, the in vitro curcumin stability and loading capacity performance were investigated. FTIR results indicated the interaction between chitosan and sodium tripolyphosphate (TPP) and other biopolymers to form the nanocarriers and also confirmed the successful curcumin loaded on the nanocarriers with the curcumin loading efficiency on all nanocarriers in the range of 58.00–60.40%. Further, the antioxidant activity of nanocarriers was examined by DPPH assay. Antioxidant activity of curcumin before and after encapsulation on the nanocarriers indicated that the encapsulation process had no disadvantageous effect on its antioxidant activity. The formed nanocarriers were exploited as biosorbents for chromium (VI) removal from an aqueous solution. The effects of pH, contact time, and initial chromium (VI) concentration were studied to optimize the conditions for maximum Cr(VI) adsorption. The Cur/Cs-ALG nanocarrier showed a suitable removal efficiency of 83% for Cr(VI) at pH 3. According to the Langmuir isotherm model, the maximum adsorption capacity of the nanocarriers for removing Cr(VI) was in the range of 217–400 mg g−1. The findings obtained from this research indicate that nanocarriers can act as excellent natural antioxidants, so these nano-complexes are appropriate not only for drug delivery systems but also for removing toxic metal ions. Therefore, we successfully encapsulated curcumin as a protective antioxidant by using nanoparticles as drug delivery carriers to remove chromium ions.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    Alieh Rezagholizade-shirvan, Mahboubeh Masrournia & Hossein Behmadi

  2. Razi Vaccine and Serum Research Institute, Mashhad Branch, Agricultural Research, Education and Extension Organization (AREEO), Mashhad, Iran

    Mohsen Fathi Najafi

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  1. Alieh Rezagholizade-shirvan
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  2. Mahboubeh Masrournia
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  3. Mohsen Fathi Najafi
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Rezagholizade-shirvan, A., Masrournia, M., Fathi Najafi, M. et al. Synthesis and characterization of nanoparticles based on chitosan-biopolymers systems as nanocarrier agents for curcumin: study on pharmaceutical and environmental applications. Polym. Bull. 80, 1495–1517 (2023). https://doi.org/10.1007/s00289-022-04095-4

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