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Green synthesis of chitosan-coated magnetic nanoparticles for drug delivery of oxaliplatin and irinotecan against colorectal cancer cells

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Abstract

Recently, the green synthesizing methods of nanoparticles found their place in the center of attention. In this regard. the synthesis of useful nanoparticles such as the magnetic types, as well as the cases of Chia seeds that can form natural mucilage and function as a capping agent, are recognized of great importance. In this work, superparamagnetic (Fe3O4) nanoparticles were prepared by using the water extract of chia seeds for the first time, which was then coated with chitosan (CS), Fe3O4@CS core–shell, and finally, exerted for the drug delivery of oxaliplatin (OXA), and irinotecan (IRI) that were labeled as Fe3O4–OXA@CS core–shell and Fe3O4–IRI@CS core–shell, respectively. The nanoparticles were characterized through the means of XRD, FTIR, UV–Vis, TEM, FESEM, DLS, zeta potential, and VSM. The results of XRD analyses confirmed the successful synthesis of superparamagnetic nanoparticles. The observed crystallity, solid-phase, and hydrodynamic sizes were indicative of particle agglomeration in the solid phase, while in comparison to the crystallite sizes and particle diameters were increased up to more than 3-folds. The occurrence of agglomeration was more apparent in the case of Fe3O4–OXA@CS core–shell. Moreover, the cytotoxicities of nano-drugs were investigated against CT-26 cancer cells by the application of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The IC50 values of Fe3O4@CS core–shell, Fe3O4–OXA@CS core–shell, and Fe3O4–IRI@CS core–shell were reported to be 246.6, 79.6, and 61.1 ppm, respectively. The cytotoxicities of drug-loaded nanoparticles were exceedingly increased when being compared to the case of Fe3O4@CS core–shell.

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References

  1. Hashemzadeh A, Drummen G, Avan A, Darroudi M, Khazaei M, Khajavian R, Rangrazi A, Mirzaei M (2021) When a metal-organic framework mediated smart drug delivery meets gastrointestinal cancers. J Mater Chem B

  2. Asgharzadeh F, Hashemzadeh A, Yaghoubi A, Avan A, Nazari SE, Soleimanpour S, Hassanian SM, Ferns GA, Rahmani F, Khazaei M (2021) Therapeutic effects of silver nanoparticle containing sulfasalazine on DSS-induced colitis model. J Drug Deliv Sci Technol 61:102133

  3. Fereydouni N, Movaffagh J, Amiri N, Darroudi S, Gholoobi A, Goodarzi A, Hashemzadeh A, Darroudi M (2021) Synthesis of nano-fibers containing nano-curcumin in zein corn protein and its physicochemical and biological characteristics. Sci Rep 11(1):1–15

    Article  Google Scholar 

  4. Naeem M, Awan UA, Subhan F, Cao J, Hlaing SP, Lee J, Im E, Jung Y, Yoo J-W (2020) Advances in colon-targeted nano-drug delivery systems: challenges and solutions. Arch Pharmacal Res 43(1):153–169

    Article  CAS  Google Scholar 

  5. Marques A, Costa P, Velho S, Amaral M (2020) Functionalizing nanoparticles with cancer-targeting antibodies: a comparison of strategies. J Control Release 320:180–200

    Article  CAS  PubMed  Google Scholar 

  6. Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Khanbabaei H, Ashrafizadeh M, Mohammadinejad R, Tavakol S, Sethi G (2020) Curcumin delivery mediated by bio-based nanoparticles: a review. Molecules 25(3):689

    Article  PubMed Central  Google Scholar 

  7. Gong F, Yang N, Wang X, Zhao Q, Chen Q, Liu Z, Cheng L (2020) Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics. Nano Today 32:100851

  8. Kievit FM, Zhang M (2011) Surface engineering of iron oxide nanoparticles for targeted cancer therapy. Acc Chem Res 44(10):853–862

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Dadfar SM, Roemhild K, Drude NI, von Stillfried S, Knüchel R, Kiessling F, Lammers T (2019) Iron oxide nanoparticles: diagnostic, therapeutic and theranostic applications. Adv Drug Deliv Rev 138:302–325

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ulbrich K, Hola K, Subr V, Bakandritsos A, Tucek J, Zboril R (2016) Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies. Chem Rev 116(9):5338–5431

    Article  CAS  PubMed  Google Scholar 

  11. Wahajuddin SA (2012) Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomed 7:3445

    Article  CAS  Google Scholar 

  12. Dulińska-Litewka J, Łazarczyk A, Hałubiec P, Szafrański O, Karnas K, Karewicz A (2019) Superparamagnetic iron oxide nanoparticles—current and prospective medical applications. Materials 12(4):617

    Article  PubMed Central  Google Scholar 

  13. Mohammed L, Gomaa HG, Ragab D, Zhu J (2017) Magnetic nanoparticles for environmental and biomedical applications: a review. Particuology 30:1–14

    Article  CAS  Google Scholar 

  14. Khan A, Sahu NK (2020) Folate encapsulation in PEG-diamine grafted mesoporous Fe3O4 nanoparticles for hyperthermia and in vitro assessment. IET Nanobiotechnol 14(9):881–888

    Article  PubMed  PubMed Central  Google Scholar 

  15. Sullivan MV, Stockburn WJ, Hawes PC, Mercer T, Reddy SM (2020) Green synthesis as a simple and rapid route to protein modified magnetic nanoparticles for use in the development of a fluorometric molecularly imprinted polymer-based assay for detection of myoglobin. Nanotechnology 32(9):095502

  16. Rahmani R, Gharanfoli M, Gholamin M, Darroudi M, Chamani J, Sadri K, Hashemzadeh A (2020) Plant-mediated synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) using aloe vera and flaxseed extracts and evaluation of their cellular toxicities. Ceram Int 46(3):3051–3058

    Article  CAS  Google Scholar 

  17. Park SB, Goldstein D, Krishnan AV, Lin CSY, Friedlander ML, Cassidy J, Koltzenburg M, Kiernan MC (2013) Chemotherapy‐induced peripheral neurotoxicity: a critical analysis. CA Cancer J Clin 63(6):419–437

  18. Argyriou AA, Bruna J, Marmiroli P, Cavaletti G (2012) Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. Crit Rev Oncol Hematol 82(1):51–77

    Article  PubMed  Google Scholar 

  19. Oun R, Moussa YE, Wheate NJ (2018) The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans 47(19):6645–6653

    Article  CAS  PubMed  Google Scholar 

  20. Tabasi H, Hamed Mosavian MT, Sabouri Z, Khazaei M, Darroudi M (2021) pH-responsive and CD44-targeting by Fe3O4/MSNs-NH2 nanocarriers for Oxaliplatin loading and colon cancer treatment. Inorg Chem Commun 125:108430. https://doi.org/10.1016/j.inoche.2020.108430

    Article  CAS  Google Scholar 

  21. Johnstone TC, Suntharalingam K, Lippard SJ (2016) The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs. Chem Rev 116(5):3436–3486

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Gholoobi A, Meshkat Z, Abnous K, Ghayour-Mobarhan M, Ramezani M, Homaei Shandiz F, Verma KD, Darroudi M (2017) Biopolymer-mediated synthesis of Fe3O4 nanoparticles and investigation of their in vitro cytotoxicity effects. J Mol Struct 1141:594–599. https://doi.org/10.1016/j.molstruc.2017.04.024

    Article  CAS  Google Scholar 

  23. Yew YP, Shameli K, Miyake M, Khairudin NBBA, Mohamad SEB, Naiki T, Lee KX (2020) Green biosynthesis of superparamagnetic magnetite Fe3O4 nanoparticles and biomedical applications in targeted anticancer drug delivery system: a review. Arab J Chem 13(1):2287–2308

    Article  CAS  Google Scholar 

  24. Aisida SO, Alnasir MH, Botha S, Bashir A, Bucher R, Ahmad I, Zhao T-k, Maaza M, Ezema FI (2020) The role of polyethylene glycol on the microstructural, magnetic and specific absorption rate in thermoablation properties of Mn-Zn ferrite nanoparticles by sol–gel protocol. Eur Polym J 132:109739

  25. Vangijzegem T, Stanicki D, Laurent S (2019) Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics. Exp Opin Drug Deliv 16(1):69–78

    Article  CAS  Google Scholar 

  26. Han H, Hou Y, Chen X, Zhang P, Kang M, Jin Q, Ji J, Gao M (2020) Metformin-induced stromal depletion to enhance the penetration of gemcitabine-loaded magnetic nanoparticles for pancreatic cancer targeted therapy. J Am Chem Soc 142(10):4944–4954

    Article  CAS  PubMed  Google Scholar 

  27. Zhang W, Taheri-Ledari R, Hajizadeh Z, Zolfaghari E, Ahghari MR, Maleki A, Hamblin MR, Tian Y (2020) Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide. Nanoscale 12(6):3855–3870

    Article  CAS  PubMed  Google Scholar 

  28. Liu D, Hong Y, Li Y, Hu C, Yip T-C, Yu W-K, Zhu Y, Fong C-C, Wang W, Au S-K (2020) Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy. Theranostics 10(3):1181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Ebrahim SA, Ashtari A, Pedram MZ, Ebrahim NA (2019) Publication trends in drug delivery and magnetic nanoparticles. Nanoscale Res Lett 14(1):1–14

    Google Scholar 

  30. Ades S (2009) Adjuvant chemotherapy for colon cancer in the elderly: moving from evidence to practice. Oncology 23(2):162–162

    PubMed  Google Scholar 

  31. Niu H, Meng Z, Cai Y (2012) Fast defluorination and removal of norfloxacin by alginate/Fe@ Fe3O4 core/shell structured nanoparticles. J Hazard Mater 227:195–203

    Article  PubMed  Google Scholar 

  32. Justin C, Samrot AV, Sahithya CS, Bhavya KS, Saipriya C (2018) Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery. PloS One 13(7):e0200440

  33. Karimi M, Ghasemi A, Zangabad PS, Rahighi R, Basri SMM, Mirshekari H, Amiri M, Pishabad ZS, Aslani A, Bozorgomid M (2016) Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem Soc Rev 45(5):1457–1501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Dutta RK, Sahu S (2012) Development of oxaliplatin encapsulated in magnetic nanocarriers of pectin as a potential targeted drug delivery for cancer therapy. Res Pharma Sci 2:38–45

    Article  Google Scholar 

  35. Munaweera I, Shi Y, Koneru B, Saez R, Aliev A, Di Pasqua AJ, Balkus KJ Jr (2015) Chemoradiotherapeutic magnetic nanoparticles for targeted treatment of nonsmall cell lung cancer. Mol Pharm 12(10):3588–3596

    Article  CAS  PubMed  Google Scholar 

  36. Fawcett D, Verduin JJ, Shah M, Sharma SB, Poinern GEJ (2017) A review of current research into the biogenic synthesis of metal and metal oxide nanoparticles via marine algae and seagrasses. J Nanosci 2017

  37. Parsian M, Unsoy G, Mutlu P, Yalcin S, Tezcaner A, Gunduz U (2016) Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug. Eur J Pharmacol 784:121–128

    Article  CAS  PubMed  Google Scholar 

  38. Wu D, Zhu L, Li Y, Wang H, Xu S, Zhang X, Wu R, Yang G (2020) Superparamagnetic chitosan nanocomplexes for colorectal tumor-targeted delivery of irinotecan. Int J Pharm 584:119394

  39. 39. Zhang Y, Qi J, Chen H, Xiong C (2021) Corrigendum to “Amphiphilic diblock copolymers inhibit the formation of encrustation on the surface of biodegradable ureteral stents in vitro and in vivo” [Colloids Surf. A: Physicochem. Eng. Asp. 610 (2021) 125667]. Colloids Surf A Physicochem Eng Asp 625:126997. https://doi.org/10.1016/j.colsurfa.2021.126997

  40. Hayashi K, Ono K, Suzuki H, Sawada M, Moriya M, Sakamoto W, Yogo T (2010) High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect. ACS Appl Mater Interfaces 2(7):1903–1911

    Article  CAS  PubMed  Google Scholar 

  41. Saboktakin MR, Tabatabaie R, Maharramov A, Ramazanov MA (2010) Synthesis and characterization of superparamagnetic chitosan–dextran sulfate hydrogels as nano carriers for colon-specific drug delivery. Carbohyd Polym 81(2):372–376

    Article  CAS  Google Scholar 

  42. Denadai ÂM, Ianzer D, Alcântara AFdC, Santoro MM, Santos CF, Lula IS, de Camargo AC, Faljoni-Alario A, dos Santos RA, Sinisterra RD (2007) Novel pharmaceutical composition of bradykinin potentiating penta peptide with β-cyclodextrin: physical–chemical characterization and anti-hypertensive evaluation. Int J Pharm 336(1):90–98

    Article  CAS  PubMed  Google Scholar 

  43. Zambito Y, Pedreschi E, Di Colo G (2012) Is dialysis a reliable method for studying drug release from nanoparticulate systems?—a case study. Int J Pharm 434(1–2):28–34

    Article  CAS  PubMed  Google Scholar 

  44. Subbiah R, Ramalingam P, Ramasundaram S, Park K, Ramasamy MK, Choi KJ (2012) N, N, N-Trimethyl chitosan nanoparticles for controlled intranasal delivery of HBV surface antigen. Carbohyd Polym 89(4):1289–1297

    Article  CAS  Google Scholar 

  45. Brito E, Gomes D, Cid CP, de Araújo J, Bohn F, Streck L, Fonseca J (2019) Superparamagnetic magnetite/IPEC particles. Colloids Surf A 560:376–383

    Article  CAS  Google Scholar 

  46. Ag M, AM ES, MS S, (2013) Current situation of water pollution and its effect on aquatic life in Egypt. Egy J Occup Med 37(1):95–115

    Article  Google Scholar 

  47. de Campo C, Dos Santos PP, Costa TMH, Paese K, Guterres SS, de Oliveira RA, Flôres SH (2017) Nanoencapsulation of chia seed oil with chia mucilage (Salvia hispanica L.) as wall material: Characterization and stability evaluation. Food Chem 234:1–9

    Article  PubMed  Google Scholar 

  48. Kuznetcova DV, Linder M, Jeandel C, Paris C, Desor F, Baranenko DA, Nadtochii LA, Arab-Tehrany E, Yen FT (2020) Nanoliposomes and nanoemulsions based on chia seed lipids: preparation and characterization. Int J Mol Sci 21(23):9079

    Article  CAS  PubMed Central  Google Scholar 

  49. da Silva SF, de Campo C, Paese K, Guterres SS, Costa TMH, Flôres SH (2019) Nanoencapsulation of linseed oil with chia mucilage as structuring material: characterization, stability and enrichment of orange juice. Food Res Int 120:872–879

    Article  Google Scholar 

  50. Hernández-Morales L, Espinoza-Gómez H, Flores-López LZ, Sotelo-Barrera EL, Núñez-Rivera A, Cadena-Nava RD, Alonso-Núñez G, Espinoza KA (2019) Study of the green synthesis of silver nanoparticles using a natural extract of dark or white Salvia hispanica L. seeds and their antibacterial application. Appl Surf Sci 489:952–961

    Article  Google Scholar 

  51. Al-Qasmi N (2021) Facial eco-friendly synthesis of copper oxide nanoparticles using chia seeds extract and evaluation of its electrochemical activity. Processes 9(11):2027

    Article  CAS  Google Scholar 

  52. Sabouri Z, Rangrazi A, Amiri MS, Khatami M, Darroudi M (2021) Green synthesis of nickel oxide nanoparticles using Salvia hispanica L. (chia) seeds extract and studies of their photocatalytic activity and cytotoxicity effects. Bioprocess Biosyst Eng 44(11):2407–2415. https://doi.org/10.1007/s00449-021-02613-8

  53. Silva VAJ, Andrade PL, Silva MPC, Bustamante DA, De Los Santos Valladares L, Albino Aguiar J (2013) Synthesis and characterization of Fe3O4 nanoparticles coated with fucan polysaccharides. J Magn Magn Mater 343:138–143. https://doi.org/10.1016/j.jmmm.2013.04.062

    Article  CAS  Google Scholar 

  54. Matei E, Predescu C, Berbecaru A, Predescu A, Trusca R (2011) Leaching tests for synthesized magnetite nanoparticles used as adsorbent for metal ions from liquid solutions. Dig J Nanomater Biostruct 6(4):1701–1708

    Google Scholar 

  55. Řezníček R, Chlan V, Štěpánková H, Novák P, Maryško M (2012) Magnetocrystalline anisotropy of magnetite. J Phys Condensed Matter 24(5):055501

  56. Sahu D, Panda N, Acharya B, Panda A (2014) Enhanced UV absorbance and photoluminescence properties of ultrasound assisted synthesized gold doped ZnO nanorods. Opt Mater 36(8):1402–1407

    Article  CAS  Google Scholar 

  57. Nalbandian L, Patrikiadou E, Zaspalis V, Patrikidou A, Hatzidaki E, Papandreou NC (2016) Magnetic Nanoparticles in medical diagnostic applications: synthesis, characterization and proteins conjugation. Curr Nanosci 12(4):455–468

    Article  CAS  Google Scholar 

  58. Sahoo Y, Goodarzi A, Swihart MT, Ohulchanskyy TY, Kaur N, Furlani EP, Prasad PN (2005) Aqueous ferrofluid of magnetite nanoparticles: fluorescence labeling and magnetophoretic control. J Phys Chem B 109(9):3879–3885

    Article  CAS  PubMed  Google Scholar 

  59. Machodi MJ, Daramola MO (2019) Synthesis and performance evaluation of PES/chitosan membranes coated with polyamide for acid mine drainage treatment. Sci Rep 9(1):1–14

    Article  CAS  Google Scholar 

  60. Balamurugan M, Saravanan S, Soga T (2014) Synthesis of iron oxide nanoparticles by using Eucalyptus globulus plant extract. e-J Surf Sci Nanotechnol 12:363–367

  61. Adewuyi A, Lau WJ (2021) Chapter 3—nanomaterial development and its applications for emerging pollutant removal in water. In: Lau WJ, Faungnawakij K, Piyachomkwan K, Ruktanonchai UR (eds) Handbook of nanotechnology applications. Elsevier, pp 67–97. https://doi.org/10.1016/B978-0-12-821506-7.00003-X

  62. Elahi B, Mirzaee M, Darroudi M, Kazemi Oskuee R, Sadri K, Amiri MS (2019) Preparation of cerium oxide nanoparticles in salvia macrosiphon boiss seeds extract and investigation of their photo-catalytic activities. Ceram Int 45(4):4790–4797. https://doi.org/10.1016/j.ceramint.2018.11.173

    Article  CAS  Google Scholar 

  63. Jaiswal MK, Gogoi M, Dev Sarma H, Banerjee R, Bahadur D (2014) Biocompatibility, biodistribution and efficacy of magnetic nanohydrogels in inhibiting growth of tumors in experimental mice models. Biomater Sci 2(3):370–380. https://doi.org/10.1039/C3BM60225G

    Article  CAS  PubMed  Google Scholar 

  64. Dorniani D, Hussein MZB, Kura AU, Fakurazi S, Shaari AH, Ahmad Z (2012) Preparation of Fe3O4 magnetic nanoparticles coated with gallic acid for drug delivery. Int J Nanomed 7:5745

    Article  CAS  Google Scholar 

  65. Huxford RC, Della Rocca J, Lin W (2010) Metal–organic frameworks as potential drug carriers. Curr Opin Chem Biol 14(2):262–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Horcajada P, Gref R, Baati T, Allan PK, Maurin G, Couvreur P, Ferey G, Morris RE, Serre C (2012) Metal–organic frameworks in biomedicine. Chem Rev 112(2):1232–1268

    Article  CAS  PubMed  Google Scholar 

  67. Horcajada P, Chalati T, Serre C, Gillet B, Sebrie C, Baati T, Eubank JF, Heurtaux D, Clayette P, Kreuz C (2010) Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nat Mater 9(2):172–178

    Article  CAS  PubMed  Google Scholar 

  68. Cunha D, Ben Yahia M, Hall S, Miller SR, Chevreau H, Elkaïm E, Maurin G, Horcajada P, Serre C (2013) Rationale of drug encapsulation and release from biocompatible porous metal–organic frameworks. Chem Mater 25(14):2767–2776

    Article  CAS  Google Scholar 

  69. Hashemzadeh A, Drummen GP, Avan A, Darroudi M, Khazaei M, Khajavian R, Mirzaei Shahrabi M, Rangrazi A (2021) When a metal-organic framework mediated smart drug delivery meets gastrointestinal cancers. J Mater Chem B 50

  70. Abney CW, Taylor-Pashow KM, Russell SR, Chen Y, Samantaray R, Lockard JV, Lin W (2014) Topotactic transformations of metal–organic frameworks to highly porous and stable inorganic sorbents for efficient radionuclide sequestration. Chem Mater 26(18):5231–5243

    Article  CAS  Google Scholar 

  71. Wu D, Zhu L, Li Y, Wang H, Xu S, Zhang X, Wu R, Yang G (2020) Superparamagnetic chitosan nanocomplexes for colorectal tumor-targeted delivery of irinotecan. Int J Pharm 584:119394. https://doi.org/10.1016/j.ijpharm.2020.119394

    Article  CAS  PubMed  Google Scholar 

  72. Kawassaki RK, Romano M, Dietrich N, Araki K (2021) Titanium and iron oxide nanoparticles for cancer therapy: surface chemistry and biological implications. Front Nanotechnol 3(68). https://doi.org/10.3389/fnano.2021.735434

  73. Darroudi M, Gholami M, Rezayi M, Khazaei M (2021) An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery. J Nanobiotechnol 19(1):399. https://doi.org/10.1186/s12951-021-01150-6

    Article  CAS  Google Scholar 

  74. Farzin A, Etesami SA, Quint J, Memic A, Tamayol A (2020) Magnetic nanoparticles in cancer therapy and diagnosis. Adv Healthc Mater 9(9):1901058

    Article  CAS  Google Scholar 

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Acknowledgments

The technical support for this work was provided by Islamic Azad University of Quchan and Mashhad University of Medical Sciences based on the MS thesis of Ms. N. Farmanbar.

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  1. Department of Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran

    Nadia Farmanbar & Sharareh Mohseni

  2. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

  3. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Darroudi

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  1. Nadia Farmanbar
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Farmanbar, N., Mohseni, S. & Darroudi, M. Green synthesis of chitosan-coated magnetic nanoparticles for drug delivery of oxaliplatin and irinotecan against colorectal cancer cells. Polym. Bull. 79, 10595–10613 (2022). https://doi.org/10.1007/s00289-021-04066-1

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