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Dual drug delivery system based on biodegradable modified poly(3-hydroxybutyrate)-NiO nanocomposite and sequential release of drugs

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Abstract

The main objective of this study is to achieve a successful nanodrug delivery platform for Norfloxacin (NF) and Tenoxicame (TX) that allows sustained drug release in the body for treatment of microbial infections and pain revival. Poly(3-hydroxybutyrate) (PHB) are the most thoroughly studied forms of biopolymer polyesters family for biomedical applications due to their biocompatibility, biodegradability, sustained release of drugs and nontoxic. Malelic anhydride is used as compatibilizer between polymer and drugs. Nickel oxide (NiO), ferromagnetic material, has been applied in the medical field and platforms for drug delivery system, so spherical crystalline NiO nanoparticles were dispersed in the polymer matrix. PHB grafted maleic anhydride/NiO nanocomposites (PHB-g-MA-NiO) was designed and used as a dual carrier for NF and TX. The crystallite size and type of interaction between functional groups were characterized by XRD and FTIR techniques. The thermal behaviour of PHB-g-MA-NiO nanocomposites was characterized by TGA and compared with PHB, PHB-g-MA. Firstly, PHB-g-MA-NiO was used with different contents of NiO as a carrier for TX. The drug release mechanism was studied using Zero-order, First-order, Higuchi, Hixon–Crowell and Korsmeyer–Peppas equations at different pH (2, 7.4). The carrier with the highest loading % of TX was loaded by NF and a mixture of NF/TX drugs. The PHB-g-MA-5%NiO nanocomposite loaded NF/TX showed potential activity against Staphylococcus aureus (Gram-positive), Klebsiella pneumonia (Gram-negative) and Bacillus cereus (Gram-positive). NF/TX/PHB-g-MA-5%NiO nanocomposite was recorded to release 100% and 14% of NF and TX, respectively after 21 days at pH = 2. The % of cumulative release of NF and TX after 504 h at pH 2 illustrated a high potential of PHB-g-MA-5%NiO nanocomposite loaded by NF/TX for usage as a drug carrier.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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  1. Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt

    Nehal Salahuddin, Mohamed Gaber, Maie Mousa & Mohamed A. Abdelwahab

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  1. Nehal Salahuddin
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  2. Mohamed Gaber
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Correspondence to Nehal Salahuddin or Mohamed A. Abdelwahab.

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Salahuddin, N., Gaber, M., Mousa, M. et al. Dual drug delivery system based on biodegradable modified poly(3-hydroxybutyrate)-NiO nanocomposite and sequential release of drugs. Polym. Bull. 79, 10969–10990 (2022). https://doi.org/10.1007/s00289-021-04029-6

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