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Synthesis of bentonite-β-cyclodextrin-iron nanoparticles composite as a magnetic adsorbent in solid-phase extraction for separation of nicotinic acid N-methylbetaine: an optimized process

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Abstract

Bentonite-β-cyclodextrin-iron nanoparticles (Ben-βCD-INP) composite was synthesized, characterized, and utilized like an innovative magnetic solid-phase extraction (MSPE) adsorbent to separate and preconcentrate nicotinic acid N-methylbetaine (NAMB). Experiment conditions to find important variables of NAMB adsorption on the Ben-βCD-INP were A: time (1–10 min), B: Adsorbent amount (0.01–0.1 g), C: pH (1–8), and for desorption were A: temperature (60–100 °C), B: concentration (0.8–1.2 M), C: time (5–15 min), and D: Volume (1–3 mL). The adsorbent contributes significantly in the extraction process. The INP in the nanocomposite makes it easy to remove the adsorbent with the help of a magnet. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and X-ray diffraction (XRD) were used to characterize the synthesized adsorbent. Experimental design was used to optimize the factors affecting extraction. NAMB in plasma samples was extracted and evaluated by a reversed-phase HPLC–UV method. The findings have shown that MSPE was able to extract NAMB efficiently. The developed HPLC–UV procedure for the determination of NAMB in human plasma, showed linear relationship in the concentration interval of 20–10,000 ng/mL (r = 0. 9998) with the limit of detection (LOD), the limit of quantitation (LOQ) and recovery (%) of 5, 18 ng/mL, and 114%, respectively. The procedure was successfully used to determine the concentration of NAMB in human plasma. This study offers a promising hybrid nano-biomaterial adsorbent in biomedical nanotechnology to selective measurement of the drug or supplements such as NAMB from plasma.

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Acknowledgements

The authors would like to thanks Miss. Fereshteh Mohammadi at biopharmaceutics laboratory in faculty of pharmacy, Kerman University of Medical Sciences, Kerman, Iran, and Miss Roushan Ahmadi in Kerman Branch, Islamic Azad University, Kerman, Iran.

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  1. Department of Analytical Chemistry, Faculty of Sciences, Kerman Branch, Islamic Azad University, Kerman, Iran

    Mahdieh Abbasi Meymand, Maryam Kazemipour & Mehdi Shahidi

  2. Department of Drug and Food Control, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

    Mehdi Ansari

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Meymand, M.A., Kazemipour, M., Shahidi, M. et al. Synthesis of bentonite-β-cyclodextrin-iron nanoparticles composite as a magnetic adsorbent in solid-phase extraction for separation of nicotinic acid N-methylbetaine: an optimized process. Polym. Bull. 79, 9093–9110 (2022). https://doi.org/10.1007/s00289-021-03944-y

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