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Preparation and characterization of methylene bisacrylamide crosslinked pectin/acrylamide hydrogels

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Abstract

By manufacturing a pH-sensitive and biocompatible interpenetrating polymer network device, the targeting of BCS III drugs in the colon and improving their absorption can be achieved. Using N, N methylene bisacrylamide as a crosslinker and ammonium persulfate as an initiator, the formed hydrogel was evaluated using an in vitro and in vivo toxicity study of pectin–acrylamide fabricated hydrogels. Fourier transform infrared confirmed the fabrication of stable pectin/acrylamide hydrogel. Swelling studies have shown that swelling is preferably increased by increasing the acrylamide content of hydrogel structures in solutions of higher pH 7.5. For the formulated formulations, porosity and sol–gel fraction were also calculated. With a rise in pectin and acrylamide content, porosity and gel fraction increased, while porosity decreased and gel fraction improved with an increase in N, N methylene bisacrylamide content. At different pH strengths of 1.2, 5.5 and 7.5, the drug release profile was also analysed. With the increasing pH of the dissolution medium, maximum drug release was seen. By fitting experimental data to model equations and determining the corresponding parameters, the release mechanisms were studied. The maximum drug release of 90% was observed in the A6 formulation. The findings showed that the kinetics of drug release from the hydrogels in the respective buffer solutions were mainly due to Fickian diffusion. The in vivo toxicity studies confirmed the safety of the prepared hydrogels and showed no toxicity.

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Authors and Affiliations

  1. Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

    Ayesha Siddiqua, Sadia Rehman & Nasreen Ramzan

  2. Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

    Nazar Muhammad Ranjha

  3. Islamia College of Pharmacy Sialkot, University of Sargodha, Sargodha, Pakistan

    Sadia Rehman, Hina Shoukat & Humaira Sultana

Authors
  1. Ayesha Siddiqua
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  2. Nazar Muhammad Ranjha
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  3. Sadia Rehman
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  4. Hina Shoukat
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  5. Nasreen Ramzan
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  6. Humaira Sultana
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Correspondence to Ayesha Siddiqua.

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Siddiqua, A., Ranjha, N.M., Rehman, S. et al. Preparation and characterization of methylene bisacrylamide crosslinked pectin/acrylamide hydrogels. Polym. Bull. 79, 7655–7677 (2022). https://doi.org/10.1007/s00289-021-03870-z

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  • DOI: https://doi.org/10.1007/s00289-021-03870-z

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