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Application of polydopamine on the implant surface modification

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Abstract

The exceptional adhesive properties of polydopamine (PDA) and its ability to perfectly fix various biomolecules and metal ions are conducive for the development of appropriate modifications of implant surfaces. Over the recent years, several combinations of different substrates and surface modification molecules and/or ions have been tested effectively with PDA. In addition, a number of these combinations were proved to have good biocompatibility and specific functions. Therefore, this article summarizes the latest developments in implant surface modification using PDA, in various fields ranging from orthopedics and dentistry to corneal and cardiovascular implants. In addition to osteogenesis, the antibacterial and anti-inflammatory functions of PDA-coated surfaces are also discussed. These studies suggest that PDA, which has strong adhesive properties and good biocompatibility, has potential for use in the surface modification of a variety of functional implants.

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Acknowledgements

This work was supported by the Fundamental Research Funds for the Central Universities (No.2020kfyXGYJ082), National Natural Science Foundation of China (No.81800984) and Natural Science Foundation of Hubei Province (No.2020CFB787).

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Authors and Affiliations

  1. Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yaoxu Li, Cheng Li, Ran Yu & Yumei Ding

  2. School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yaoxu Li, Cheng Li, Ran Yu & Yumei Ding

  3. Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, 430022, China

    Yaoxu Li, Cheng Li, Ran Yu & Yumei Ding

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  1. Yaoxu Li
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Li, Y., Li, C., Yu, R. et al. Application of polydopamine on the implant surface modification. Polym. Bull. 79, 5613–5633 (2022). https://doi.org/10.1007/s00289-021-03793-9

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