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Improved thermal stability metal oxide/GO-based hybrid materials for enhanced Anti-inflammatory and Antioxidant activity

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Abstract

In this work, a series of metal oxide/graphene oxide hybrid heterostructures were synthesized by a solution phase in situ method without the use of any template or surfactant. The as-synthesized materials were characterized by different characterization techniques such as X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), Raman and transmission electron microscopy (TEM). It was found that the surface of graphene oxide was decorated highly by different metal oxide (MeO) nanoparticles. Further, thermogravimetric analysis (TGA) measurements showed the enhanced thermal stability of graphene oxide (GO) with respect to oxygen functional groups in composites. The as-synthesized materials, i.e., GO, pure MeO and MeO/GO nanocomposites were examined for antioxidant activity using in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical assay. Considerable in vitro antioxidant activities in a concentration-dependent manner were recorded. Interestingly, composite TiO2-GO showed more elevated scavenging efficiency than GO in DPPH tests. Also, in vitro anti-inflammatory activity of MeO-GO nanocomposites was evaluated using inhibition of protein denaturation. The nanocomposites CdO/GO and Ag2O/GO show significant increase in the protein denaturation inhibition ability when compared with GO.

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Acknowledgements

Authors are highly thankful to NIT Srinagar for help and support. The award of senior Research Fellowship to JA from CSIR New Delhi is highly acknowledged [File No. 09/984(0003)].

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  1. Physical Chemistry Lab, Department of Chemistry, National Institute of Technology, Srinagar, J&K, 190 006, India

    Jahangir Ahmad & Kowsar Majid

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Ahmad, J., Majid, K. Improved thermal stability metal oxide/GO-based hybrid materials for enhanced Anti-inflammatory and Antioxidant activity. Polym. Bull. 78, 3889–3911 (2021). https://doi.org/10.1007/s00289-020-03304-2

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