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Fabrication of trichlorovinylsilane-modified-chitosan film with enhanced solubility and antibacterial activity

Polymer Bulletin volume 77, pages 5811–5824 (2020)Cite this article

Abstract

Here, trichlorovinylsilane-modified-chitosan (TVS-m-CS) film is synthesized and explicated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy and X-ray diffraction (XRD). The SEM micrograph of TVS-m-CS revealed smooth structure with bulge surface. The TVS-m-CS antibacterial activity was evaluated using the broth dilution and agar diffusion methods. Results herein indicated that the TVS-m-CS exhibited enhanced water solubility (67 mg/mL) compared to the cross-linked chitosan (CS) film (5.5 mg/mL). Notably, TVS-m-CS showed a significantly enhanced antibacterial activity against E. coli, S. aureus, E. faecalis, Kleb spp. and methicillin-resistant Staphylococcus aureus (minimum inhibitory concentration [MIC] = 0.078–0.156 mg/mL and minimum bactericidal concentration [MBC] = 12.5–3.12 mg/mL) than the original CS film. Unlike most quaternized chitosan derivatives, the TVS-m-CS was prepared via an easy and simple route and exhibited a comparatively high antibacterial performance. The time-kill study revealed that 5 mg/mL TVS-m-CS exposed to the bacteria cells is sufficient to give a ~ 0.08 log10 reduction (> 99.9% kill rate) within 24 h.

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Authors and Affiliations

  1. Polymeric Materials Research Laboratory, Chemistry Department, Faculty of Arts and Science, Eastern Mediterranean University, Famagusta, Mersin 10, TR North Cyprus, Turkey

    Anthony Udukhomo Awode, Akeem Adeyemi Oladipo, Osman Yilmaz & Mustafa Gazi

  2. Department of Medical Microbiology, Dr. Fazıl Küçük Faculty of Medicine, Eastern Mediterranean University, Famagusta, Mersin 10, TR North Cyprus, Turkey

    Mumtaz Guran

Authors
  1. Anthony Udukhomo Awode
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  2. Akeem Adeyemi Oladipo
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  3. Mumtaz Guran
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  4. Osman Yilmaz
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  5. Mustafa Gazi
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Correspondence to Akeem Adeyemi Oladipo or Mustafa Gazi.

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Awode, A.U., Oladipo, A.A., Guran, M. et al. Fabrication of trichlorovinylsilane-modified-chitosan film with enhanced solubility and antibacterial activity. Polym. Bull. 77, 5811–5824 (2020). https://doi.org/10.1007/s00289-019-03056-8

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  • DOI: https://doi.org/10.1007/s00289-019-03056-8

Keywords

  • Chitosan antibacterial activity
  • Time-kill study
  • Vinylsilane
  • Minimum bactericidal concentration
  • Water solubility