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A facile method to fabricate an antimicrobial coating based on poly(1-vinyl-3-allylimidazolium iodide) (PAVI) and poly(ethylene glycol) dimethyl acrylate (PEGDMA)

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Abstract

Biomedical device-related infections have been a great concern over the past decades. In this work, cationic macromolecules poly(1-vinyl-3-allylimidazolium iodide) (PAVI) with antibactericidal ability were prepared and grafted on nose clips by surface-initiated polymerization via plasma/autoclaving method. The precursor poly(1-vinylimidazole) was synthesized by surface-initiated polymerization and then quaternarized to form polymeric quaternary ammonia salts which have been commonly used as bactericidal materials. We first synthesized a series of different formulations of cationic PAVI and hydrophilic poly(ethylene glycol) dimethyl acrylate graftings onto nose clips by thermal-initiating polymerization with covalent bonds for antimicrobial surface modification. Antibacterial test results showed that the cationic–hydrophilic coatings exhibited excellent antibacterial behaviors for multidrug-resistant bacteria such as vancomycin-resistant Enterococcus and methicillin-resistant Staphylococcus aureus. The in vitro log reduction value for could reach 6.0 and 8.6, respectively, and the in vivo log reduction value could reach 1.3 and 2.0, respectively. In vitro cytotoxicity indicated that PAVI coatings were non-leachable and exhibited no toxicity toward mammal cells. This rationally designed polycationic antimicrobial coating displayed great potential application in combating implant-associated infections on biomedical devices.

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Acknowledgements

This work was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). We also thank the fund support by Changsha University of Science and Technology.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Changsha University of Science and Technology, Changsha, 410114, Hunan, China

    Bo Liu & Jingshi Liang

  2. School of Chemical and Biomedical Engineering, Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore, 637459, Singapore

    Chao Zhou

  3. College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China

    Hongqin Song & Jianghua Li

  4. Department of Materials Science and Engineering, National University of Singapore, Singapore, 119260, Singapore

    Feifei Zhang

  5. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100080, China

    Jun Liu

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  1. Chao Zhou
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Zhou, C., Song, H., Zhang, F. et al. A facile method to fabricate an antimicrobial coating based on poly(1-vinyl-3-allylimidazolium iodide) (PAVI) and poly(ethylene glycol) dimethyl acrylate (PEGDMA). Polym. Bull. 76, 5433–5449 (2019). https://doi.org/10.1007/s00289-018-2637-y

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