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Ornidazole-loaded polyethylene glycol-based micron-level particles: influence of eutectic liquid on reservoir-type particle formation, drug entrapment efficiency and drug dissolution or release behavior

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Abstract

A temperature-controlled dispersion technique was used to develop ornidazole-loaded micron-level particles. To overcome the problem of generating the reservoir-type particles from polyethylene glycol, the influence of camphor and menthol (1:1 ratio)-based eutectic liquid on reservoir-type particle formation, drug entrapment efficiency and drug release behavior was examined. A distinct wall formation was observed for the particles on contact with water. Higher drug entrapment efficiency (~ 15–20%) was noted for the particles prepared with eutectic liquid. Significantly, (one-way ANOVA) higher t50% values (35.16 ± 1.44 min for HCl and 43.6 ± 0.76 min for pH 6.8 phosphate buffer) were noticed for the eutectic liquid-based particles in comparison with the t50% values (30.66 ± 0.76 min for HCl and 35.5 ± 0.86 min for pH 6.8 phosphate buffer) observed for the particles made without the same. The potential of eutectic liquid to generate the microcapsule structure should be explored further.

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Abbreviations

ANOVA:

Analysis of variance

DEE:

Drug entrapment efficiency

ORN:

Ornidazole

PEG:

Polyethylene glycol

PIB:

Polyisobutylene

SEM:

Scanning electron microscope

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Acknowledgements

The authors would like to acknowledge the management of Lovely Professional for providing the facilities to perform the experimental works.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi, G.T.Road (NH-1), Phagwara, Jalandhar, Punjab, 144411, India

    Shunmugaperumal Tamilvanan & Puja Chanda

  2. National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, C/O NETES Institute of Technology and Science, NH-37, Shantipur, Parli Part, Mirza, Assam, 781125, India

    Shunmugaperumal Tamilvanan

Authors
  1. Shunmugaperumal Tamilvanan
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  2. Puja Chanda
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Contributions

P.C. performed the experimental works, and S.T. supervised the project. Both of them contributed to the data analysis and production of the manuscript.

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Correspondence to Shunmugaperumal Tamilvanan.

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All the authors declare that they have no conflict of interest.

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Tamilvanan, S., Chanda, P. Ornidazole-loaded polyethylene glycol-based micron-level particles: influence of eutectic liquid on reservoir-type particle formation, drug entrapment efficiency and drug dissolution or release behavior. Polym. Bull. 76, 4389–4398 (2019). https://doi.org/10.1007/s00289-018-2608-3

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  • DOI: https://doi.org/10.1007/s00289-018-2608-3

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