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Synthesis and characterization of amphiphilic triblock copolymers including β-alanine/α-methyl-β-alanine and ethylene glycol by “click” chemistry

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Abstract

Terminally azide poly-β-alanine (PBA-Az) was directly obtained by hydrogen transfer polymerization of acrylamide in the presence of sodium azide as an initiator. However, terminally azide poly(α-methyl β-alanine) (PmBA-Az) was synthesized by the reaction between terminally bromo poly(α-methyl β-alanine) and sodium azide. Dipropargyllated polyethylene glycol (PEG-di-Pr) was synthesized by using the reaction of PEGs with different molecular weights and propargyl bromide. Synthesis of poly(β-alanine-b-ethylene glycol-b-β-alanine) and poly(α-methyl β-alanine-b-ethylene glycol-b-α-methyl β-alanine) amphiphilic ABA triblock copolymers was achieved via “click” chemistry of PBA-Az or PmBA-Az and PEG-di-Pr with different molecular weight. “Click” reaction parameters such as concentration and time were assessed. Macromonomers and the amphiphilic triblock copolymers were characterized by using 1H-NMR, FT-IR, MALDI-MS, TGA, and elemental analysis techniques. The multi-instruments studies of the obtained amphiphilic triblock copolymers reveal that the copolymers easily formed as a result of “click” chemistry.

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Authors and Affiliations

  1. Department of Chemistry, Ordu University, 52200, Ordu, Turkey

    Efkan Çatıker

  2. Department of Chemistry, Giresun University, 28200, Giresun, Turkey

    Ergül Meyvacı & Temel Öztürk

  3. Department of Chemistry, Hacettepe University, 06800, Ankara, Turkey

    Mehmet Atakay & Bekir Salih

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  1. Efkan Çatıker
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  2. Ergül Meyvacı
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  3. Mehmet Atakay
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  5. Temel Öztürk
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Correspondence to Temel Öztürk.

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Çatıker, E., Meyvacı, E., Atakay, M. et al. Synthesis and characterization of amphiphilic triblock copolymers including β-alanine/α-methyl-β-alanine and ethylene glycol by “click” chemistry. Polym. Bull. 76, 2113–2128 (2019). https://doi.org/10.1007/s00289-018-2561-1

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