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Simple and efficient approach for improved cytocompatibility and faster degradation of electrospun polycaprolactone fibers

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Abstract

A simplified method to modify electrospun PCL fibers for better degradation and cytocompatibility is proposed. The surface modification was achieved by preparing fibers having pores and subsequent alkali treatment. The modifications were studied by comparing hydrolyzed PCL mats, porous PCL mats and hydrolyzed porous PCL mats with unmodified PCL mats. The in vitro degradation analyzed in simulated wound fluid and biological response using L-929 cells confirmed surface-hydrolyzed porous PCL fibers as non-cytotoxic with enhanced cell adhesion, viability and degradability. The proposed modification will be suitable to fabricate implantable electrospun scaffolds.

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Acknowledgements

The authors acknowledge the financial support from the Department of Science and Technology, Grant number SR/FT/LS-128/2009 to AKPR. The authors thank Ms. Nimi N for contact angle measurements and Mr. Nishad for scanning electron microscopy analysis.

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Authors and Affiliations

  1. Division of Tissue Culture, Department of Applied Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Biomedical Sciences and Technology, Thiruvananthapuram, Kerala, 695 012, India

    Aswathy Bhaskaran, Tilak Prasad, T. V. Kumary & P. R. Anil Kumar

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  1. Aswathy Bhaskaran
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  2. Tilak Prasad
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  3. T. V. Kumary
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  4. P. R. Anil Kumar
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Correspondence to P. R. Anil Kumar.

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Bhaskaran, A., Prasad, T., Kumary, T.V. et al. Simple and efficient approach for improved cytocompatibility and faster degradation of electrospun polycaprolactone fibers. Polym. Bull. 76, 1333–1347 (2019). https://doi.org/10.1007/s00289-018-2442-7

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  • DOI: https://doi.org/10.1007/s00289-018-2442-7

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