Synthesis and characterization of antipyrine-imprinted polymers and their application for sustained release
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In view of technological significance of molecularly imprinted polymers (MIPs) in drug delivery, the ‘grafting from’ approach was employed to develop surface-imprinted silica particles for selective recognition and sustained delivery of a pharmaceutical drug antipyrine (ANP). ANP–MIP was fabricated using methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker by UV irradiation via iniferter approach. Voltammetric measurements was used to scale the extraction and rebinding of ANP on glassy carbon electrode with Pt wire as counter electrode, Ag/AgCl as reference electrode. Various parameters were optimized for ascertaining the performance of ANP–MIP such as time, temperature, and pH. Grafted MIP was characterized by FTIR, thermogravimetry, elemental analysis, surface morphology (AFM) besides the recognition, rebinding and selectivity studies. Calibration curve linearly increases in concentration range of 0.1–2.0 mM with correlation coefficient R2 = 0.976 and limit of detection (LOD) as 0.448 µg mL−1. Thus, fabricated ANP–MIP was studied for controlled release of drug under varying conditions.
KeywordsMolecular imprinting Surface-imprinted polymer Iniferter Antipyrine Controlled release
Authors acknowledge Department of Chemistry, Banaras Hindu University for AFM analysis. AK acknowledges UGC and BHU for university research fellowship. Financial assistance from DST, New Delhi is acknowledged (Grant no. EMR/2016/005245).
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