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Peptoids and polypeptoids: biomimetic and bioinspired materials for biomedical applications

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Abstract

As material chemists and engineers aim to improve the properties of macromolecules for advanced biomedical applications, considerable attention has been paid to new classes of biomimetic polymers such as polypeptoids. Peptoid polymers can be synthesized from a wide variety of chemically diverse building blocks to create a broad family of functionally diverse materials. These materials have been shown to have a wide variety of biological activities and promising attributes. The ability to mimic nature’s self-organization has become important in the area of biomaterials science. In this short colloquy, we provide an overview of the chemistry of peptoid/peptoid polymers including several applications. The discovery of few remarkable peptoids/polypeptoids of biological interest outlined over the past few decades will be discussed.

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Acknowledgements

This work was done under the Czech-American Scientific Co-Operation. Work at Tomas Bata University in Zlin was supported by the Ministry of Education, Youth and Sports of the Czech Republic within the framework project entitled “Synthesis of polypeptoid nanosheets for biomineralization” (Project No. LH 14050), falling under the program for international cooperation in research and development LH-KONTAKT II, and Work at the Molecular Foundry was supported by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231.

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  1. Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tř. T. Bati 5678, Zlin, 760 01, Czech Republic

    Shimoga D. Ganesh, Nabanita Saha, Oyunchimeg Zandraa & Petr Sáha

  2. Biological Nanostructures Facility, Molecular Foundry, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA, 94720, USA

    Ronald N. Zuckermann

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  1. Shimoga D. Ganesh
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Correspondence to Nabanita Saha.

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Ganesh, S.D., Saha, N., Zandraa, O. et al. Peptoids and polypeptoids: biomimetic and bioinspired materials for biomedical applications. Polym. Bull. 74, 3455–3466 (2017). https://doi.org/10.1007/s00289-016-1902-1

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