Polymer Bulletin

, Volume 73, Issue 10, pp 2661–2675 | Cite as

Fumaric acid cross-linked carboxymethylcellulose/poly(vinyl alcohol) hydrogels

Original Paper

Abstract

Carboxymethylcellulose (CMC)/poly(vinyl alcohol) (PVA) hydrogels were synthesized by crosslinking in presence of fumaric acid (FA) and characterized with different methods (FTIR, TGA/DTG, XRD and SEM) of analysis. The water absorbencies of these hydrogels in different pH solutions were investigated. The equilibrium swelling capacity of the gels reduced due to increasing crosslinking between CMC and PVA. pH sensitivity and reversibility of hydrogels were also investigated. The results indicated that the hydrogels had pH reversibility behavior which swelled at pH = 8 and shrinked at pH = 2.6. The FTIR results pointed toward the cross-linking reaction between carboxyl group of FA with hydroxyl groups of PVA and NaCMC through ester formation. The crosslinking improved the thermal stability of the hydrogels. SEM analysis showed highly porous structure for 10FA and 15FA hydrogels.

Keywords

Carboxymethylcellulose Poly(vinyl alcohol) Fumaric acid Swelling Hydrogel 

References

  1. 1.
    Peppas NA, Bures P, Leobandung W, Ichikawa H (2000) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27–46CrossRefGoogle Scholar
  2. 2.
    Park K, Shalaby WSW, Park H (1993) Biodegradable Hydrogels for Drug Delivery. Technomic Publishing Co, LancasterGoogle Scholar
  3. 3.
    Peppas NA (1986, 1987) Hydrogels in medicine and pharmacy. CRC Press Inc., Boca Raton [(vol. l–3), vol. 1. Fundamentals, pp vii + 180; vol. 2. Polymers, pp vii + 171; vol. 3. Properties and applications, pp vii + 195]Google Scholar
  4. 4.
    Rowley J, Madlambayan G, Faulkner J, Mooney DJ (1999) Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 20:45–53CrossRefGoogle Scholar
  5. 5.
    Kim SW, Bae YH, Okano T (1992) Hydrogels: swelling, drug loading and release. Pharm Res 9(3):283–290CrossRefGoogle Scholar
  6. 6.
    Esposita FE, Nobile MA, Mensitieri C, Nicolais L (1996) Water sorption in cellulose-based hydrogels. J Appl Polym Sci 60:2403–2407CrossRefGoogle Scholar
  7. 7.
    Charpentier D, Mocanu G, Carpov A, Chapelle S, Merle L, Muller G (1997) New hydrophobically modified carboxymethylcellulose derivatives. Carbohydr Polym 33:177–186CrossRefGoogle Scholar
  8. 8.
    Mitsumata T, Suemitsu Y, Fujii K, Fujii T, Taniguchi T, Koyama K (2003) pH-response of chitosan, K-corrageenan, carboxymethyl cellulose sodium salt complex hydrogels. Polymer 44:7103–7111CrossRefGoogle Scholar
  9. 9.
    Chiellini E, Corti A, D’Antone S, Solaro R (2003) Biodegradation of poly(vinylalcohol) based materials. Prog Polym Sci 28(6):963–1014CrossRefGoogle Scholar
  10. 10.
    Nuttelman CR, Mortisen DJ, Henry SM, Anseth KS (2001) Attachment of fibronectin to poly(vinyl alcohol) hydrogels promotes NIH3T3 cell adhesion, proliferation, and migration. J Biomed Mater Res 57:217–223CrossRefGoogle Scholar
  11. 11.
    Taleb M, Abd El-Mohdy H, Abd El-Rehim A (2009) Radiation preparation of PVA/CMC copolymers and their application in removal of dyes. J Hazard Mater 168:68–75CrossRefGoogle Scholar
  12. 12.
    El-Salmawi KM, Abu Zaid MM, Ibraheim SM, El-Naggar AM, Zahran AH (2001) Sorption of dye wastes by poly(vinyl alcohol)/poly(carboxymethyl cellulose) blend grafted through a radiation method. J Appl Polym Sci 82:136–142CrossRefGoogle Scholar
  13. 13.
    Xiao C, Gao Y (2008) Preparation and properties of physically crosslinked sodium carboxymethyl-cellulose/poly(vinyl alcohol) complex hydrogels. J Appl Polym Sci 107:1568–1572CrossRefGoogle Scholar
  14. 14.
    Xiao C, Li H, Gao Y (2009) Preparation and properties of physically crosslinked sodium carboxymethyl-cellulose/poly(vinyl alcohol) complex hydrogels. Polym Int 58:112–115CrossRefGoogle Scholar
  15. 15.
    El-Zawawy WK (2006) Blended graft copolymer of carboxymethyl cellulose and poly(vinyl alcohol) with banana fiber. J Appl Polym Sci 100:1842–1848CrossRefGoogle Scholar
  16. 16.
    Wang S, Zhang Q, Tan B, Liu L, Shi L (2011) pH-sensitive poly(Vinyl alcohol)/sodium carboxy-methylcellulose hydrogel beads for drug delivery. J Macromol Sci Part B Phys 50:2307–2317CrossRefGoogle Scholar
  17. 17.
    El-Salmawi KM (2007) Application of polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC) hydrogel produced by conventional crosslinking or by freezing and thawing. J Macromol Sci Part A Pure Appl Chem 44:619–624CrossRefGoogle Scholar
  18. 18.
    Buhus G, Popa M, Peptu C, Desbrieres J (2007) Hydrogels based on carboxymethylcellulose and poly (vinyl alcohol) for controlled loading and release of chloramphenicol. J Optoelectron Adv Mater 9(11):3445–3453Google Scholar
  19. 19.
    El-Sayed S, Mahmoud KH, Fatah AA, Hassen A (2011) Hydrogels based on carboxymethylcellulose and poly (vinyl alcohol) for controlled loading and release of chloramphenicol. Phys B 406:4068–4076CrossRefGoogle Scholar
  20. 20.
    Rao KM, Mallikarjuna B, Krishna Rao KSV, Prabhakar MN, Chowdoji Rao K, Subha MCS (2012) Preparation and characterization of pH sensitive poly(vinyl alcohol)/sodium carboxymethyl cellulose IPN microspheres for in vitro release studies of an anti-cancer drug. Polym Bull 68:1905–1919CrossRefGoogle Scholar
  21. 21.
    Akar E, Altınışık A, Seki Y (2012) Preparation of pH- and ionic-strength responsive biodegradable fumaric acid crosslinked carboxymethyl cellulose. Carbohydr Polym 90:1634–1641CrossRefGoogle Scholar
  22. 22.
    Qiu H, Yu J (2008) Polyacrylate/(carboxymethylcellulose modified montmorillonite) superabsorbent nanocomposite. J Appl Polym Sci 107:118–123CrossRefGoogle Scholar
  23. 23.
    Ma J, Xu Y, Fan B, Liang B (2007) Preparation and characterization of sodiumcarboxy-methylcellulose/poly(N-isopropylacrylamide)/clay semi-IPN nanocomposite hydrogels. Eur Polym J 43:2221–2228CrossRefGoogle Scholar
  24. 24.
    Tiwari A, Mishra AK, Kobayashi H, Turner APF (2012) Intelligent nanomaterials, 1st edn. Wiley, London, p 506Google Scholar
  25. 25.
    Schott H (1992) Swelling kinetics of polymers. J Macromol Sci B 31:1–9CrossRefGoogle Scholar
  26. 26.
    Yizhe W, Xiaoning S, Wenbo W, Aiqin W (2013) Synthesis, characterization, and swelling behaviors of a pH-responsive CMC-g-poly(AA-co-AMPS) superabsorbent. Turk J Chem 37:149–159Google Scholar
  27. 27.
    Zhai NH, Wang WB, Wang AQ (2011) Synthesis and swelling characteristics of a pH-responsive guar gum-g-poly(sodium acrylate)/medicinal stone superabsorbent composite. Polym Compos 32:210–218CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Chemistry Department, Graduate School of Natural and Applied SciencesDokuz Eylül UniversityIzmirTurkey
  2. 2.Faculty of Sciences, Department of ChemistryDokuz Eylül UniversityIzmirTurkey

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