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[6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release

Polymer Bulletin volume 71, pages 3163–3176 (2014)Cite this article

Abstract

[6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW ~ 3 × 104 g/mol) fibers (375 ± 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that ~97 % of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 °C, whereas only ~74 % of it could be done from the corresponding films. About 92 % of [6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was ~65 %.

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Acknowledgments

Research grants from The Thailand Research Fund (TRF)/Mahidol University (TRG5680070); Thailand Ministry of Science and Technology; Faculty of Science, Mahidol University to T.V.; and from TRF/Commission on Higher Education to P.T. (RTA5480007) are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand

    Thanaporn Chantarodsakun, Thammasit Vongsetskul, Patoomratana Tuchinda, Sukanda Uamsiri, Chuthamas Bamrungcharoen & Pramuan Tangboriboonrat

  2. Center for Innovation Development and Technology Transfer, Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhonprathom, 73170, Thailand

    Kulachart Jangpatarapongsa

  3. Department of Biology, Faculty of Science, Mahidol University, Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand

    Supeecha Kumkate

  4. School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Pathum Thani, 12120, Thailand

    Pakorn Opaprakasit

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  1. Thanaporn Chantarodsakun
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Correspondence to Thammasit Vongsetskul.

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Chantarodsakun, T., Vongsetskul, T., Jangpatarapongsa, K. et al. [6]-Gingerol-loaded cellulose acetate electrospun fibers as a topical carrier for controlled release. Polym. Bull. 71, 3163–3176 (2014). https://doi.org/10.1007/s00289-014-1243-x

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  • DOI: https://doi.org/10.1007/s00289-014-1243-x

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