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pH-/temperature-sensitive carboxymethyl chitosan/poly(N-isopropylacrylamide-co-methacrylic acid) IPN: preparation, characterization and sustained release of riboflavin

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Abstract

Dual crosslinked pH-/temperature-sensitive interpenetrating polymer networks (IPN) were prepared by free-radical copolymerization of N-isopropylacrylamide and methylacrylic acid (MAA) using N,N′-methylenebisacrylamide as a crosslinker in carboxymethyl chitosan (which was crosslinked by Ca2+) aqueous solution. Scanning electron microscopy was used to observe the morphologies of the IPN at different pH values and temperatures. The effects of MAA content and environmental pH on the “pH-/temperature-induced” phase transition behavior of the IPN hydrogels were investigated. The phase transition temperature was adjusted to 37 °C by changing the MAA content. The effects of drug-loaded content, crosslinking density, environmental pH, and temperature on the drug release behavior of the drug-loaded IPN hydrogel were also explored. Based on results, the hydrogel possessed pH/temperature sensitivity. The swelling ratio and phase translation temperature of the hydrogel were lower at lower pH. These values were lowest at pH 3.0. The release behavior of riboflavin was dependent on preparation condition, environmental pH, and temperature. Drug cumulative release was only 6 % at pH 1.8 for 2 h. The drug cumulative release was 13 % before the drug-loaded hydrogel reached the position with pH 6.8. The drug release rate was higher at lower temperature. Therefore, dual-crosslinked hydrogel holds much potential as a drug site-specific carrier.

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Acknowledgments

The authors are grateful to the Doctoral and Professorial Funds of Chongqing University of Science and Technology of China (CK2011B23).

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, 401331, People’s Republic of China

    Shilan Chen & Yong Chen

  2. State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, People’s Republic of China

    Shilan Chen, Mingzhu Liu & Shuping Jin

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  1. Shilan Chen
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  2. Mingzhu Liu
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Correspondence to Shilan Chen.

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Chen, S., Liu, M., Jin, S. et al. pH-/temperature-sensitive carboxymethyl chitosan/poly(N-isopropylacrylamide-co-methacrylic acid) IPN: preparation, characterization and sustained release of riboflavin. Polym. Bull. 71, 719–734 (2014). https://doi.org/10.1007/s00289-013-1088-8

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  • DOI: https://doi.org/10.1007/s00289-013-1088-8

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