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Synthesis, characterization and in vitro drug release property of amino acid end-capped aliphatic polycarbonates

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Abstract

A series of amino acid end-capped aliphatic polycarbonates (CV-PDTC)s was synthesized via ring-opening polymerization of 2,2-dimethyl trimethylene carbonate initiated by N-carbobenzyloxy-l-valine without metallic catalyst. The chemical structure of CV-PDTC was verified by Fourier transform infrared spectra, nuclear magnetic resonance spectra (1H NMR) and gel permeation chromatography. The molecular weight of CV-PDTC could be adjusted by varying reaction condition. The thermal behavior of resultant polycarbonates was measured by differential scanning calorimetry, the result indicated that the crystalline property was related to the structure. The drug release results demonstrated that CV-PDTC had a good sustained-release effect for drug, and that the release behavior was controlled by a diffusion–degradation mechanism.

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Acknowledgments

The authors are grateful for the financial support of Hubei Province Natural Science Foundation (No. 2010CDB03501), the Open Project Program of Hubei Province Key Laboratory of Coal Conversion and New Carbon Materials (No. WKDM201105).

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Authors and Affiliations

  1. Hubei Province Key Laboratory of Coal Conversion and New Carbon Materials, College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, 430081, China

    Yu Zhou, Xin Xie, Jun Jie Zeng, Jun Ge & Hong Xiang Chen

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  1. Yu Zhou
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  2. Xin Xie
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  3. Jun Jie Zeng
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Correspondence to Yu Zhou.

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Zhou, Y., Xie, X., Zeng, J.J. et al. Synthesis, characterization and in vitro drug release property of amino acid end-capped aliphatic polycarbonates. Polym. Bull. 71, 673–683 (2014). https://doi.org/10.1007/s00289-013-1085-y

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  • DOI: https://doi.org/10.1007/s00289-013-1085-y

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