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pH-sensitive IPN hydrogel based on poly (aspartic acid) and poly (vinyl alcohol) for controlled release

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Abstract

Various pH-sensitive sequential interpenetrating polymer network (IPN) hydrogels were prepared by introducing poly (vinyl alcohol) (PVA) hydrogel into Poly (aspartic acid) (PASP) hydrogel by freeze-thawing treatment to obtain a novel drug delivery system to the intestine. The structure and the morphologies of the prepared hydrogels were studied by Fourier Transform Infrared Spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal behavior and crystallinity of the hydrogels were characterized by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Their pH-sensitive properties moreover were studied and the results revealed that both PASP hydrogel and IPN hydrogels exhibited excellent pH-sensitivity. Furthermore, the controlled drug release properties of the hydrogels were also evaluated and results indicated that by increasing the PVA fraction in the IPN hydrogel, the release of Naproxen sodium was improved. These results show that the IPN hydrogels could be a suitable carrier for site-specific drug delivery in the intestine.

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Acknowledgments

The authors express their thanks for the supports from the Natural Science Foundation of China (21076009), the (863) High Technology Project (2008AA062401) and the Programs for New Century Excellent Talents in the University (NCET-100212) and the Project sponsored by SRF for ROCS, SEM (LXJJ2012-001).

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Authors and Affiliations

  1. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China

    Miaomiao Liu, Lilin Wang, Haijia Su, Hui Cao & Tianwei Tan

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  1. Miaomiao Liu
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  2. Lilin Wang
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  3. Haijia Su
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  4. Hui Cao
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  5. Tianwei Tan
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Correspondence to Haijia Su.

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Liu, M., Wang, L., Su, H. et al. pH-sensitive IPN hydrogel based on poly (aspartic acid) and poly (vinyl alcohol) for controlled release. Polym. Bull. 70, 2815–2827 (2013). https://doi.org/10.1007/s00289-013-0990-4

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  • DOI: https://doi.org/10.1007/s00289-013-0990-4

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