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Synthesis and characterization of star-shaped poly(d,l-lactide)-block-poly(ethylene glycol) copolymers

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Abstract

Star-shaped hydroxy-terminated poly(d,l-lactide) (s-PDLLA), with arms of different lengths, were obtained by ring-opening polymerization (ROP) of d,l-lactide (LA) initiated by varied contents of pentaerythritol (PETH) in the presence of stannous octoate (Sn(Oct)2), and were condensed with carboxyl-terminated poly(ethylene glycol) methyl ether (CT-mPEG, M n = 850 and 2,000) to afford four-arm star-shaped poly(d,l-lactide)-block-poly(ethylene glycol) copolymer (s-PDLLA-b-PEG). The polymers, including s-PDLLA, CT-mPEG, and s-PDLLA-b-PEG, were characterized and confirmed by 1H-NMR and 13C-NMR spectroscopy, fourier transform infrared spectroscopy (FT-IR), and gel permeation chromatography (GPC).

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Acknowledgments

The authors gratefully acknowledge the financial support through GNSF (Guangdong Natural Science Foundation) grant 07300675, Guangdong Key Laboratory for High-Property & Functional Polymeric Materials grant 2008-1, the Presidential Fund for Innovation of South China Agriculture University grant 4200-K07254, the Presidential Fund of College of Resource and Environment of South China Agriculture University, the Fund of Central Government-Guangdong Province Co-construct Laboratory (Biotechnical Pharmaceutics Engineering Laboratory) Project (2007–2010), the Fund of Central Government-Ministry of Education-Guangdong Province Industry-Academia-Research Project grant 2006D90501003.

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Authors and Affiliations

  1. Department of Pharmaceutical Engineering, College of Resources and Environment, South China Agriculture University, 510642, Guangzhou, China

    Yaling Lin

  2. Department of Polymer Material Science and Engineering, College of Material Science and Engineering, South China University of Technology, 510641, Guangzhou, China

    Anqiang Zhang

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  1. Yaling Lin
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  2. Anqiang Zhang
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Correspondence to Yaling Lin.

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Lin, Y., Zhang, A. Synthesis and characterization of star-shaped poly(d,l-lactide)-block-poly(ethylene glycol) copolymers. Polym. Bull. 65, 883–892 (2010). https://doi.org/10.1007/s00289-010-0252-7

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  • DOI: https://doi.org/10.1007/s00289-010-0252-7

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