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Novel hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) polymeric micelles as amphotericin B carriers

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Abstract

A series of amphiphilic hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) (HPAE-co-PLGA) copolymers were synthesized by ring-opening polymerization of dl-lactide, glycolide and a fourth generation hyperbranched poly (amine-ester) (HPAE-OHs4) with Sn(Oct)2 as catalyst. The chemical structure of copolymers was characterized by Fourier transform infrared (FT-IR), nuclear magnetic resonance (1H-NMR, 13C-NMR), thermo gravimetric analysis apparatus (TGA), and different scanning calorimetry (DSC). Formation and characteristics of polymeric micelles of the amphiphilic copolymer were studied by environmental scanning electron microscopy (ESEM), fluorescence spectroscopy, and dynamic light scattering (DLS). In order to estimate the feasibility as novel drug carriers, a lipophilic model drug amphotericin B was incorporated into polymeric micelles and the drug release behavior was investigated. The micelle size and drug-loading content were found increased, and the drug-release rate decreased with the increase of molar ratio of dl-lactide/glycolide to HPAE.

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Acknowledgment

This project was supported by the major program for fundamental research of the Chinese Academy of Sciences, China (No: KJCX2-YW-M02); the State Key Development Program for Basic Research of China (973) (No: 2009CB930200).)

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Authors and Affiliations

  1. National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China

    Tiewei Wang & Yan Wu

  2. China Agricultural University, Beijing, 100083, China

    Tiewei Wang

  3. The first affiliated Hospital of Jiamusi University, Jiamusi, 154002, China

    Mingjun Li

Authors
  1. Tiewei Wang
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  2. Yan Wu
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Correspondence to Yan Wu.

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Wang, T., Wu, Y. & Li, M. Novel hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) polymeric micelles as amphotericin B carriers. Polym. Bull. 65, 425–442 (2010). https://doi.org/10.1007/s00289-009-0218-9

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  • DOI: https://doi.org/10.1007/s00289-009-0218-9

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