Summary
Microscale hydroxyapatite (HAp), a well-known biocompatible substance for the regeneration and reinforcement of damaged bones, was composited with chitosan as a counter-polymer to produce a film with both biocompatibility and flexibility. Homogeneously dispersed solutions of microscale HAp powder and chitosan with various concentrations of HAp and chitosan were prepared in an attempt to optimize the characteristics of the film at room temperature using a molding method. The physiochemical and morphological properties of the prepared film were analyzed by thermal gravimetric analysis, Fourier transform infrared spectroscopy and field emission scanning electron microscopy. The prepared film showed high flexibility with homogeneous distribution of chitosan powders in the whole film. The results suggest that a biocompatible film of microscale HAp can be applied in various fields, such as the surface modification of bone implants, regeneration of damaged bones, osteoporosis to improve biocompatible interface between osteoblast cells and microscale inorganic materials, and to improve the osteoconductivity of bone regeneration
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References
Ohbayashi Y, Miyake M, Nagahata S (2000) Biomaterials 21:509
Itoha S, Kikuchib M, Koyamac Y, Takakudac K, Shinomiyaa K, Tanaka J (2002) Biomaterials 23:3919
Kim YG, Seob DS, Lee JK (2008) J Phys Chem Solids 69:1556
Thompson JB, Kindt JH, Drake B, Hansma HG, Morse DE, Hansma PK (2001) Nature 414:773
Kobayashi T, Nakamura S, Yamashita K (2001) J Biomed Mater Res 57:477
Guo C, Liu H and Katayama I (2002) J Dent Res 81:254
Onumaa K, Yamagishi K, Oyane A (2005) J Cryst Growth 282:199
Uchida A, Araki N, Shinto Y, Yoshikawa H, Ono K, Kurisaki E (1990) J Bone Joint Surg 72-B:298
Jansen JA, De Ruijter JE, Schaeken HG, Van Der Waerden JPCMA, Planell JA, Driessens FCM (1995) J Mater Sci: Mater Med 11:653
Oktar FN, Kesenci K, Pişkin E (1999) Artif Cells Blood Substit Immobil Biotechnol 27:367
De Lange GL, De Putter C, De Wijs FLJA (2004) J Biomed Mater Res 24:829
Ducheyne P, De Groot K (2004) J Biomed Mater Res 15:441
Ryu SC, Lim BK, Kim SH, Chen H, Koh K, Hwang YH, Kim HS, Lee J (2008) Dent Mater, submitted
Lamy D, Pierre AC, Heimann RB (1996) J Mater Res 11:680
Gross KA, Berndt CC (1994) J Mater Sci: Mater Med 5:1573
Dalton JE, Cook SD, Thomas KA, Kay JF (1995) J Bone Joint Surg Am 77:97
Yamaguchi I, Tokuchi K, Fukuzaki H, Koyama YK (2001) J Biomed Mater Res 55:20
Cooke FW (1992) Clin Orthop Rel Res 276:135
Prudden JF, Migel P, Hanson P, Friedrich L, Balassa L (1970) Am J Surg 119:560
Lahiji A, Sohrabi A, Hungerford DS, Frondoza CG (2000) J Biomed Mater Res 51:586
Mori T, Okumura M, Matsuura M, Ueno K, Tokura S, Okamoto Y, Minami S, Fujinaga T (1997) Biomaterials 18:947
Mori T, Irie Y, Nishimura SI, Tokura S, Matsuura M, Okumura M, Kadosawa T, Fujinaga T (1998) J Biomed Mater Res 43:469
Sechriest VF, Miao YJ, Niyibizi C, Westerhausen-Larson A, Matthew HW, Evans CH, Fu FH, Suh JK (2000) J Biomed Mater Res 49:534
VandeVord PJ, Matthew HWT, DeSilva SP, Mayton LB (2002) J Biomed Mater Res 59:585
Aoki H (1991) Science and Medical Applications of Hydroxyapatite. Takayama Press System Center Co. Inc., Tokyo
Ryu SC, Lim BK, Kim HS, Park YM (2007) Kor J Mater Res 17:544
Joscheka S, Niesa B, Krotzc R, Göpferich A (2000) Biomaterials 21:1645
Stoch A, Brozek A, Błazewicz S, Jastrzebski W, Stoch J, Adamczyk A, Roj IJ (2003) J Mol Struct 651–653:389
Chang MC, Tanaka J (2002) Biomaterials 23:4811
Ashok M, Sundaram NM, Kalkura SN (2003) Materials Letters 57:2066
Toyama T, Dokushima T, Yasue T, Arai Y (1998) Inorg Mater 5:479
Qu X, Wirse’n A, Albertsson AC (2000) Polymer 41:4841
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Kim, SH., Lim, BK., Sun, F. et al. Preparation of High Flexible Composite Film of Hydroxyapatite and Chitosan. Polym. Bull. 62, 111–118 (2009). https://doi.org/10.1007/s00289-008-1008-5
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DOI: https://doi.org/10.1007/s00289-008-1008-5