Skip to main content
SpringerLink
Log in

Semi-IPN hydrogels based on Poly(vinyl alcohol) for controlled release studies of chemotherapeutic agent and their Swelling characteristics

  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

Poly (vinyl alcohol)/poly(acryl amide-co-acrylamidoglycolic acid) (PVA/Poly(Am-co-AGA) based pH sensitive semi interpenetrating (semi-IPN) hydrogels were prepared by free radical polymerization in aqueous solution using N, N-methelene-bis-acryl amide (MBA) as a crosslinker. Different hydrogels with different compositions of AGA and MBA were prepared and characterized by Fourier transform infrared spectroscopy. The developed hydrogels were used for controlled release of 5-fluorouracil (5-FU). The drug entrapment efficiency up to 55% was achieved. The 5-FU loaded gels were characterized by X- ray diffraction and differential scanning calorimetric techniques, to understand the nature of drug in the polymeric matrix. The release of 5-FU through the semi-IPN was completed with in ∼12 h. Swelling studies performed in water have been analyzed with the help of an empirical equation to investigate the diffusion mechanism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wang KL, Burban JH, Cussler EL (1993) Adv Polym Sci 110:67

    Article  CAS  Google Scholar 

  2. Kayaman N, Kazan D, Erarslaan A, Okay OBM (1998) J Appl Polym Sci 67:805

    Article  CAS  Google Scholar 

  3. Sperling LH (1981) Interpenetrating Polymer Networks and Related Materials. Plenum, New York

    Google Scholar 

  4. Kiguchi T, Aota H, Matsumoto A (2003) J Polym Sci Part A 41:606

    Article  CAS  Google Scholar 

  5. Dhathathreyan A, Baskar G, Ramasami T (2002) Langmuir 18:4704

    Article  CAS  Google Scholar 

  6. Krishna Rao KSV, Subha MCS, Sairam M, Halligudi SB, Aminabhavi TM (2006) Desig Monom Polym 9:261

    Article  Google Scholar 

  7. Blanco I, Cicala G, Faro CL, Recca A (2003) J Appl Polym Sci 89:268

    Article  CAS  Google Scholar 

  8. Buyanov AL, Kuznetzov YP, Khripunov AK, Revelskaya LG (2001) J Appl Polym Sci 80:1452

    Article  CAS  Google Scholar 

  9. Kim SJ, Yoon SG, Lee YM, Kim IY, Kim SI (2003) J Appl Polym Sci 88:1346

    Article  CAS  Google Scholar 

  10. Dirk S (2006) Adv Drug Deliv Rev 58:1655

    Article  CAS  Google Scholar 

  11. Thomas JB, Creecy CM, McGinity JW, Peppas NA (2006) Polym Bull 57:11

    Article  CAS  Google Scholar 

  12. Chuang WY, Young TH, Yao CH, Chiu WY (1999) Biomaterials 20:1479

    Article  CAS  Google Scholar 

  13. Krishna Rao KSV, Naidu BVK, Subha MCS, Sairam M, Aminabhavi TM (2006) Carbohy Polym 66:333

    Article  CAS  Google Scholar 

  14. Martien FL (1986) Encyclopedia of Polymer Science and Engineering. Wiley, New York, vol 17, p 167

  15. Muhlebach A, Muller B, Pharisa C, Hofmann M, Seiferling B, Guerry D (1997) Polym Sci Part A 35:3603

    Article  Google Scholar 

  16. Yeom CK, Lee KH (1996) J Membr Sci 109:257

    Article  CAS  Google Scholar 

  17. Kim KJ, Lee SB, Han NW (1993) Polym J 25:129

    CAS  Google Scholar 

  18. Matsuyama H, Teramoto M, Urano H (1997) J Membr Sci 126:151

    Article  CAS  Google Scholar 

  19. Heidelberger C (1982) Cancer Medicine, (Lea and febiger, Philadelphia, 2nd edn) 801

  20. Waxman S, Scanlon KJ, Greenspan EM (1982) Clinical interpretation and practice in chemotheraphy. Raven Press, New Yark, p 38

    Google Scholar 

  21. Sommadossi JP, Gewirtz DA, Diasio RB, Aubert C, Cano JP, Goldman ID (1982) J Biol Chem 257:8171

    CAS  Google Scholar 

  22. Einmahl S, Zignani M, Varesio E, Heller J, Veuthey JL, Tabatabay C, Gurny R (1999) Int J Pharm 185:189

    Article  CAS  Google Scholar 

  23. Garcia O, Trigo RM, Blanco MD, Teijon JM (1994) Biomaterials, 15:689

    Article  CAS  Google Scholar 

  24. Peisker V (1994) Vademecum Internacional. Medicom, Madrid, p 848

    Google Scholar 

  25. Robert CRR, Buri PA, Peppas NA (1985) J Appl Polym Sci 30:301

    Article  CAS  Google Scholar 

  26. Peppas NA, Franson NM (1983) J Polym Sci Part B 21:983

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Changwon National University, 641-773, Changwon, South Korea

    K. S. V. Krishna Rao & Yong-Ill Lee

  2. Department of Chemistry, Sri Krishnadevaraya University, 515 003, A.P., Anantapur, India

    A. B. V. Kiran Kumar, K. Madhusudhan Rao & M. C. S. Subha

Authors
  1. K. S. V. Krishna Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. B. V. Kiran Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Madhusudhan Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. C. S. Subha
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yong-Ill Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. S. V. Krishna Rao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krishna Rao, K.S.V., Kiran Kumar, A.B.V., Madhusudhan Rao, K. et al. Semi-IPN hydrogels based on Poly(vinyl alcohol) for controlled release studies of chemotherapeutic agent and their Swelling characteristics . Polym. Bull. 61, 81–90 (2008). https://doi.org/10.1007/s00289-008-0925-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-008-0925-7

Keywords

Search

Navigation