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Preparation of β-Cyclodextrin-Dextran Polymers and their Use as Supramolecular Carrier Systems for Naproxen

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Summary

Dextran, previously activated by periodate oxidation, was grafted with mono-6-amino-6-deoxy-β-cyclodextrin, mono-6-ethylenediamino-6-deoxy-β-cyclodextrin, and mono-6-butylenediamino-6-deoxy-β-cyclodextrin by reductive alkylation in the presence of NaBH4. The polymers were able to form inclusion complexes with Naproxen, increasing the solubility of the drug by 2.2-2.6 folds. The β-cyclodextrin-grafted dextrans were used as macromolecular carriers for Naproxen, improving the “in vivo” anti-inflammatory activity of the drug.

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Authors and Affiliations

  1. Center for Enzyme Technology, University of Matanzas, Matanzas, 44740, Cuba

    Hector L. Ramirez, Aymara Valdivia & Reynaldo Villalonga

  2. Laboratory of Bioinorganic Chemistry, Havana University, Havana, 10400, Cuba

    Roberto Cao & Maysa Baños

  3. Department of Chemical Engineering, Universitat Rovira i Virgili, 43007, Tarragona, Spain

    Alex Fragoso

  4. Faculty of Pharmacy, University of Santiago de Compostela, Campus Universitario Sur, 15782, Santiago de Compostela, Spain

    Juan Jose Torres Labandeira

Authors
  1. Hector L. Ramirez
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  2. Aymara Valdivia
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  3. Roberto Cao
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  4. Alex Fragoso
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  5. Juan Jose Torres Labandeira
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  6. Maysa Baños
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  7. Reynaldo Villalonga
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Correspondence to Reynaldo Villalonga.

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Ramirez, H., Valdivia, A., Cao, R. et al. Preparation of β-Cyclodextrin-Dextran Polymers and their Use as Supramolecular Carrier Systems for Naproxen. Polym. Bull. 59, 597–605 (2007). https://doi.org/10.1007/s00289-007-0803-8

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  • DOI: https://doi.org/10.1007/s00289-007-0803-8

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