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Gel biomachine based on muscle proteins


We have created an ATP-fueled soft gel machine constructed from muscle proteins. Chemically cross-linked gels of the polymer-actin complex of the length several decades times the length of native actin filament (F-actin) move on myosin-coated surface with a velocity as high as that of native F-actin, by coupling to ATP hydrolysis. The motility observed in muscle protein-gels suggests that one might construct a soft machine fueled by chemical energy using actin and myosin molecules as elements. We have investigated the growth process of polymer-actin complexes and the correlation between the polarity and the motility of polymer-actin complex gels.

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Correspondence to Jian Ping Gong.

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Kwon, H., Shikinaka, K., Kakugo, A. et al. Gel biomachine based on muscle proteins. Polym. Bull. 58, 43–52 (2007).

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  • Cationic Polymer
  • Ammonium Cation
  • Actin Monomer
  • Actin Bundle
  • Fluorescence Microscope Image