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Nafcillin release from poly(acrylic acid–co–methyl methacrylate) hydrogels

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Summary

Copolymeric poly(acrylic acid-co-methyl methacrylate) hydrogels for three different compositions: (90/10), (80/20) and (60/40), have been studied. Drug release has been examined as a function of the hydrogel composition by HPLC (High Pressure Liquid Cromatography). The release experiments were carried out at 37 °C. The fraction of available drug release was linear in t1/2. The values of the diffusional coefficient (0.50<n<1.0) indicate that the nafcillin release mechanism from the hydrogels in study is non-Fickian. The diffusion coefficients for this drug release have been calculated. The molecular diffusion of nafcillin through hydrogels is controlled by the swelling.

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Authors and Affiliations

  1. Grupo de Nuevos Materiales y Espectroscopia Supramolecular, Facultad de Ciencias y Tecnología, Campus de Lejona, Universidad del País Vasco (UPV/EHU), Apartado 644, 48080, Bilbao, Spain

    Issa Katime, Virginia Sáez & Estíbaliz Hernáez

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  1. Issa Katime
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  2. Virginia Sáez
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  3. Estíbaliz Hernáez
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Correspondence to Issa Katime.

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Katime, I., Sáez, V. & Hernáez, E. Nafcillin release from poly(acrylic acid–co–methyl methacrylate) hydrogels. Polym. Bull. 55, 403–409 (2005). https://doi.org/10.1007/s00289-005-0453-7

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  • DOI: https://doi.org/10.1007/s00289-005-0453-7

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