Abstract.
The aim of this paper is to carry out a stability analysis for periodic breathing in humans that incorporates the dynamic characteristics of ventilation control. A simple CO2 model that takes into account the main elements of the respiratory system, i.e. the lungs and the ventilatory controller with its dynamic properties, is presented. This model results in a three-dimensional non-linear delay differential system for which there exists a unique equilibrium point. Our stability analysis of this equilibrium point leads to the definition of a new explicit stability criterion and to the demonstration of the existence of a Hopf bifurcation. Numerical simulations illustrate the influence of physiological parameters on the stability of ventilation, and particularly the major role of the dynamic characteristics of the respiratory controller.
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Received: 2 February 1999 / Revised version: 18 June 1999 / Published online: 23 October 2000
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Vielle, B. A new explicit stability criterion for human periodic breathing<--RID="*"--><--ID="*" This research was supported by grants from DRED (96-920).-->. J Math Biol 41, 546–558 (2000). https://doi.org/10.1007/s002850000061
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DOI: https://doi.org/10.1007/s002850000061