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Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle

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Abstract

A minimal model describing the embryonic cell division cycle at the molecular level in eukaryotes is analyzed mathematically. It is known from numerical simulations that the corresponding three-dimensional system of ODEs has periodic solutions in certain parameter regimes. We prove the existence of a stable limit cycle and provide a detailed description on how the limit cycle is generated. The limit cycle corresponds to a relaxation oscillation of an auxiliary system, which is singularly perturbed and has the same orbits as the original model. The singular perturbation character of the auxiliary problem is caused by the occurrence of small Michaelis constants in the model. Essential pieces of the limit cycle of the auxiliary problem consist of segments of slow motion close to several branches of a two dimensional critical manifold which are connected by fast jumps. In addition, a new phenomenon of exchange of stability occurs at lines, where the branches of the two-dimensional critical manifold intersect. This novel type of relaxation oscillations is studied by combining standard results from geometric singular perturbation with several suitable blow-up transformations.

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Acknowledgments

I. Kosiuk thanks the Max Planck Institute for Mathematics in the Sciences in Leipzig for providing a post-doctoral scholarship funding this research. I. Kosiuk and P. Szmolyan thank the Max Planck Institute for Mathematics in the Sciences in Leipzig and Technische Universität Wien for support and hospitality during several mutual visits. We are also grateful for financial support from the Vienna Science and Technology Fund (WWTF) through Project MA14-049.

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Authors and Affiliations

  1. Max Planck Institute for Mathematics in the Sciences, Inselstraße 22, 04103, Leipzig, Germany

    Ilona Kosiuk

  2. Institute for Analysis and Scientific Computing, Technische Universität Wien, Wiedner Hauptstraße 8-10, 1040, Vienna, Austria

    Peter Szmolyan

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  1. Ilona Kosiuk
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  2. Peter Szmolyan
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Correspondence to Ilona Kosiuk.

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Kosiuk, I., Szmolyan, P. Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle. J. Math. Biol. 72, 1337–1368 (2016). https://doi.org/10.1007/s00285-015-0905-0

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  • DOI: https://doi.org/10.1007/s00285-015-0905-0

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