Abstract.
In an infinite population the frequency distribution of individuals carrying a given number of mutations obeys a set of recursion equations, the equilibrium solution of which describes the mutation-selection balance. Although this solution is well-known in the case of a multiplicative-fitness landscape, where it is assumed that all mutations are deleterious and that each new mutation reduces the fitness of the individual by the same fraction, we are not aware of the existence of an analytical solution for the full dynamics. Using the generating function approach, we present here an explicit analytical solution for the frequency distribution recursion equations valid for all generations and initial conditions.
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This research was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Proj. No. 99/09644-9. The work of J.F.F. was supported in part by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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Maia, L., Botelho, D. & Fontanari, J. Analytical solution of the evolution dynamics on a multiplicative-fitness landscape. J. Math. Biol. 47, 453–456 (2003). https://doi.org/10.1007/s00285-003-0208-8
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DOI: https://doi.org/10.1007/s00285-003-0208-8