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Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects

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Abstract

The 3p21.31 locus has been associated with severe COVID-19 prognosis in GWAS studies. Here, we evaluated whether three polymorphisms (LZTFL1 rs10490770, CXCR6 rs2234355 and rs2234358) in the reported locus were associated with the need for mechanical ventilation, hospitalization length and death in 102 COVID-19 hospitalized Brazilian subjects. No genetic association was found with the need for mechanical ventilation and hospitalization length. CXCR6 rs2234355 was associated with mortality under the codominance model, with carriers of the A/A genotype having a greater chance of death than A/G (OR: 10.5; 95% CI: 1.55–70.76). Our results further suggest that the CXCR6 genetic variant contributes to COVID-19 outcomes.

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Funding

We acknowledge support from the Rede Corona-ômica BR MCTI/FINEP affiliated with RedeVírus/MCTI (01.20.0029.000462/20 404096/2020-4; 1227/21 01.22.0074.00); Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (315592/2021-4); Financiadora de Estudos e Projetos - FINEP (0494/20 01.20.0026.00; 1228/21 01.22.0082.00; 1139/20 01.20.0076.00); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES (Finance Code 001) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais—FAPEMIG (APQ-00475-20).

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Authors and Affiliations

  1. Grupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    João Locke Ferreira de Araújo, Renato Santana Aguiar & Renan Pedra de Souza

  2. Departamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Minas Gerais – Brazil, Belo Horizonte, MG, Brazil

    Victória Frigério Bonifácio, Lorena Medeiros Batista & Luciana Bastos-Rodrigues

  3. Hospital Eduardo de Menezes, Belo Horizonte, MG, Brazil

    Renata Eliane de Ávila

  4. Instituto D’OR de Pesquisa e Ensino, Rio de Janeiro, RJ, Brazil

    Renato Santana Aguiar

Authors
  1. João Locke Ferreira de Araújo
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  2. Victória Frigério Bonifácio
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  3. Lorena Medeiros Batista
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  4. Renata Eliane de Ávila
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  5. Renato Santana Aguiar
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  6. Luciana Bastos-Rodrigues
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  7. Renan Pedra de Souza
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Contributions

All authors contributed to the study’s conception. JLFA: conducted data curation, visualization, investigation, analysis, and original draft writing. VFB: conducted data curation, visualization, investigation, and analysis. LMB and REA: conducted data curation. RSA and LBA: Conceptualized the experimental design, provided supervision, obtained funding, and reviewed the manuscript. RPS: Conceptualized the experimental design, provided primary supervision, obtained funding, reviewed, and edited the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Luciana Bastos-Rodrigues or Renan Pedra de Souza.

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Conflict of Interest

The authors did not show any conflict of interest.

Ethics Approval

This study was conducted following the ethical principles established in the declaration of Helsinki and was approved by the UFMG Human Ethics Committee (protocol number: 31095820.4.0000.5149).

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de Araújo, J.L.F., Bonifácio, V.F., Batista, L.M. et al. Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects. Curr Microbiol 80, 319 (2023). https://doi.org/10.1007/s00284-023-03437-3

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