Abstract
As COVID-19 pandemic has strikingly hit the health systems of many countries, thus, the assessment of disease severity and its correlation with clinical and biochemical markers has become a necessity. These predictors can help in the diagnostics and therapeutics of COVID_19 and future viral respiratory tract infections. This was a cross-sectional study to assess the association between inflammatory makers and chronic conditions on computed tomography (CT) severity score, and D-dimer as a surrogate marker of disease severity. The results showed that inflammatory markers, age, were positively and significantly correlated with D-dimer, but inversely with oxygen saturation (SPO2). CT score showed similar pattern with exception of C-reactive protein. Vaccines had positive impact on CT severity score and Neutrophil to lymphocyte ration. These favorable outcomes provide us with affirmation regarding WHO and other international organizations that encourage people to take vaccines and especially patients, who suffer chronic diseases. The ramifications of the results are vast and pave the pathway to manage and assess COVID-19 patients in Iraq healthcare facilities.
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Abbreviations
- CRP:
-
C-reactive protein
- CT:
-
Computed tomography
- IL6:
-
Interleukin 6
- NLR:
-
Neutrophil to lymphocyte ratio
- SPO2:
-
Oxygen saturation
- WHO:
-
World health organization
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ARM: Conceptualization, design of the study, data interpretation, supervision, review and editing, project administration and supervision. MSN: patients’ recruitment and sample analysis. AA: data interpretation, data statistical analysis, writing, original draft preparation. AMK: analysis, processing and managing of data and figures. All authors have read and agreed to the published version of the manuscript.
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This study was conducted in accordance with the principles of Helsinki and approved by the ethical and scientific committee of the Department of Food Health and Nutrition (No.107 in 19/8/2021).
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Written consents were collected from the participants and independently reviewed by Alhilla teaching hospital administration. All information were kept confidential, and anonymity of participants was assured.
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Mulakhudair, A.R., Naser, M.S., Akour, A. et al. Assessment of the Correlation Between Inflammatory Status and Severity of COVID-19: Experience from Tertiary Hospital in Iraq. Curr Microbiol 80, 283 (2023). https://doi.org/10.1007/s00284-023-03407-9
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DOI: https://doi.org/10.1007/s00284-023-03407-9