Abstract
Cytomegalovirus (CMV) reactivation remains a common opportunistic infection with a prominent role in immune reconstitution in organ transplant recipients. CMVs as important drivers of natural killer (NK) cell differentiation has been indicated to prompt several phenotypic and functional alteration in these cells. We aimed to monitor the reconstitution of NK cells and change the signature of inflammatory proteins at the critical phase of CMV reactivation over six months after kidney transplantation. The present study indicated that CMV reactivation is associated with the development of IL-6, IL-10, and cytotoxic granules, including granzyme-B and granulysin, and the drop in the frequency of CD16 + NKG2A-CD57 + NK cell subset in kidney transplant recipients (KTRs) with reactivation versus non- reactivated ones. Our findings describe distinct immune signatures that emerged with CMV reactivation after kidney transplantation, which may be helpful in the timely management of CMV infection in KTRs.
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Acknowledgements
This work was supported by Shiraz University of Medical Sciences [Grant No.13843]. We thank the Abu Ali Sina Transplant Hospital, Shiraz (Shiraz, Iran), and participants for collecting samples.
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SS, RY, MH-K, BG, and JR conceived the idea and designed the study. SS has performed the experiments and written the manuscript. RY, MH-K, BG, and JR critically revised the article. All authors contributed to the article and approved the final manuscript.
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Soleimanian, S., Yaghobi, R., Karimi, M.H. et al. Altered Signatures of Plasma Inflammatory Proteins and Phonotypic Markers of NK Cells in Kidney Transplant Patients upon CMV Reactivation. Curr Microbiol 80, 9 (2023). https://doi.org/10.1007/s00284-022-03116-9
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DOI: https://doi.org/10.1007/s00284-022-03116-9